| STUDY ON THE ANTI—TUMOR EFFICACY INDUCED BY HEAT SHOCK PROTEIN 70—PEPTIDE COMPLEXES DERIVED FROM TUMOR CELLS |
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| 引用本文： | 傅庆国
,张玮
,孟凡东
,郭仁宣
,姚振宇.STUDY ON THE ANTI—TUMOR EFFICACY INDUCED BY HEAT SHOCK PROTEIN 70—PEPTIDE COMPLEXES DERIVED FROM TUMOR CELLS[J].中国医学科学杂志,2002,17(3):153-156. |
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| 作者姓名： | 傅庆国 张玮 孟凡东 郭仁宣 姚振宇 |
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| 摘 要： | Heatshockprotein７０（HSP７０）derivedfromtumocellscouldelicitstronganti－tumorimmunity（１，２）．IcarriesmultipletumorantigenicpeptidescalledHSP７０－peptidecomplexes（HSP７０－PC）．HSP７０chaper－oningtumorantigenicpeptideisexpressedontumorcellmembran
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| 关 键 词： | 肿瘤 热应激蛋白70－肽复合物 肿瘤疫苗 |
STUDY ON THE ANTI-TUMOR EFFICACY INDUCED BY HEAT SHOCK PROTEIN 70-PEPTIDE COMPLEXES DERIVED FROM TUMOR CELLS |
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| Qingguo Fu,Wei Zhang,Fandong Meng,Renxuan Guo,Zhenyu Yao.STUDY ON THE ANTI-TUMOR EFFICACY INDUCED BY HEAT SHOCK PROTEIN 70-PEPTIDE COMPLEXES DERIVED FROM TUMOR CELLS[J].Chinese Medical Sciences Journal,2002,17(3):153-156. |
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| Authors: | Qingguo Fu Wei Zhang Fandong Meng Renxuan Guo Zhenyu Yao |
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| Institution: | The Second General Surgery Department, the First Affiliated Hospital of China Medical University, Shenyang 110001. |
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| Abstract: | OBJECTIVE: To study the efficacy and explore the mechanism of the anti-tumor immunity elicited by heat shock protein 70-peptide complexes (HSP70-PC) derived from tumor cells. METHODS: Cells culture, flow cytometric analysis, affinity chromatography for protein purification, SDS-PAGE, Western-blotting and animal experiment were used. RESULTS: HSP70-PC immunization rendered protective effect to both naive tumorl-bearing mice. All of the naive mice obtained complete resistance to Hcaf cell attack; 40% of the tumor-bearing mice survived for over 90 days, whereas the mice of control group died within 2 weeks (P < 0.01). CD8+ subset of T lymphocytes in the peripheral blood of immunized mice increased by 12%. CONCLUSION: HSP70-PC induces anti-tumor immunity via activation of cytotoxic T lymphocytes (CTLs), and it possesses strong tumor vaccine effect. Our research adds more evidence to support the clinical use of HSP70-PC to fight human cancers. |
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