健脾益肾中药配合化疗治疗晚期肿瘤疗效及免疫指标的临床观察

目的：观察健脾益肾中药配合化疗治疗晚期肿瘤患者的疗效及其免疫指标的变化。方法：将101例恶性肿瘤患者随机分为治疗组（中药加化疗）54例，对照组（单纯化疗）47例，治疗2个疗程后，观察其病灶大小变化及毒副反应，并观察治疗前后卡氏评分、体重、免疫学、外周血细胞等指标变化。结果：治疗组CD3、CD4、CD4／CD8、NK细胞、卡氏评分等免疫指标及生活质量均有不同程度提高，与对照组比较差异有显著性（P＜0．05，P＜0．01），但在晚期患者的毒副反应等方面，两组比较差异无显著性。结论：提示健脾益肾中药配合化疗能提高晚期肿瘤患者的免疫功能。

Clinical Observation on Effect of Chemotherapy Combined with Chinese Medicine in Treating Advanced Tumor Patients and on Immunologic Parameters

Objective: To observe the effects of chemotherapy combined with Chinese herbal medicine (Spleen Kidney tonifying) in treating advanced tumor patients and on immune parameters. Methods: One hundred and one advanced tumor patients were randomly divided into the treated group (54 patients) treated by Chinese medicine combined with chemotherapy, and the control group (47 patients) treated by chemotherapy alone. After being treated for 8 weeks (2 treatment courses), the changes of tumor size, body weight, Karnofsky scores, immunologic parameters, peripheral blood cells, as well as the toxic and side effects were also studied. Results: Improvement of various degree was obtained on the immunologic parameters such as CD 3,CD 4,CD 4/CD 8,NK cells, and the quality of life, as Karnofsky score in the treated group, in comparing with those in the control group the difference was significant (P<0 05, P<0 01). But on behalf of the toxic and side effects in advanced patients, there was no significant difference between the two groups. Conclusion: Chemotherapy combined with Chinese Spleen Kidney tonifying drugs could improve the immunologic functions in the advanced tumor patients.