| Abstract: | Objective: The present study was undertaken to examine the effect of carbon photon on healing of skin wounds in a rat model.Methods: One full-thickness skin wounds were created on the back of Wistar rats and irradiated by using carbon photon at peak wavelength 662 nm with 54 J/cm2,compared with injured sham-irradiation control rats. The animals were then killed after various intervals of wounding,and the wounded skin tissues were evaluated by histological test.. The wound re-epithelialization and healing qualification were examined by histological analysis.Cell proliferation was examined by Brd Uimmunohis through chemical staining.Results: The irradiation of carbon photon significantly accelerated wound healing rate compared with the control group at 7,14 and 21 days after wounding. At the histological level,the significant increasement in the degree of re-epithelialization,the content of collagen and the density of micro-vessel were observed in the wound sites in carbon photon treated group at 7,14 and21 days after wounding. Moreover,treatment with carbon photon increased Brd U-labeled cells at the edge of the wound sites after wounding at the indicated time.Conclusion: The results of the experiment showed that carbon photon therapy can accelerate wound healing and improve wound healing quality by stimulating cell proliferation. |
