| 血小板激活因子及其受体拮抗剂对创伤性脊髓水肿的影响 |
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| 引用本文： | 肖建如,袁中平,赵定麟,贾连顺,侯铁胜,李医明. 血小板激活因子及其受体拮抗剂对创伤性脊髓水肿的影响[J]. 解放军医学杂志, 1996, 0(2) |
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| 作者姓名： | 肖建如 袁中平 赵定麟 贾连顺 侯铁胜 李医明 |
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| 作者单位： | 第二军医大学长征医院 |
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| 摘 要： | 采用猫鞘内注射血小板激活因子（ＰＡＦ）及静脉注射ＰＡＦ受体拮抗剂ＢＮ５２０２１观察其对猫脊髓损伤后脊髓水肿的影响。结果显示，ＰＡＦ能够增加损伤后脊髓组织含水量及Ｎａ＋、Ｃａ２＋含量；降低Ｋ＋、Ｍｇ２＋含量；ＢＮ５２０２１而能够降低伤后脊髓组织含水量，维持脊髓组织Ｎａ＋、Ｋ＋、Ｃａ２＋、Ｍｇ２＋含量的相对稳定，提示ＰＡＦ及其受体在创伤性脊髓水肿的病理生理过程中起重要作用，而ＰＡＦ受体拮抗剂能有效地减轻创伤性水肿。
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| 关 键 词： | 脊髓；创伤和损伤；水肿；血小板激活因子 |
EFFECT OF PLATELET ACTIVATING FACTOR AND ITS RECEPTOR ANTAGONIST ONTRAUMATIC SPINAL CORD EDEMA |
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| Xiao Jianru, Yuan Zhongping,Zhao Dinglin et al.. EFFECT OF PLATELET ACTIVATING FACTOR AND ITS RECEPTOR ANTAGONIST ONTRAUMATIC SPINAL CORD EDEMA[J]. Medical Journal of Chinese People's Liberation Army, 1996, 0(2) |
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| Authors: | Xiao Jianru Yuan Zhongping Zhao Dinglin et al. |
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| Abstract: | The effect of platelet activating factor(PAF )and its antagonist BN5202l on spinal cord edema fol-lowing spinal cord injury of cats was observed after they were injected intrathecally and intrarvenously on spinalcord edema following spinal cold injury. Results showed that PAF could increase water content,Na+,Ca2+ levelsand decrease K+,Mg2+ levels in spinal cord tissue after tuauma; BN52021 could evidently decrease water contentand sustain the relative stability of Na+,K+,Ca2+,Mg2+levels.It suggested that PAF and PAF receptor playedan important role in the pathophysiological process of traumatic spinal cord edema,PAF antagonist could effec-tively improve traumatic spinal cord edema. |
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| Keywords: | spinal cord wounds and injuries edema platelet activating factor |
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