冠心病微血栓与血栓素B_2、6－酮－前列腺素F_（1α）的临床关系

对冠心病微循环中有微血栓者（１５例，简称血栓组）及无微血栓者（１４例，简称无栓组），在小剂量肝素治疗前后进行了ＴＸＢ２、６－Ｋ－ＰＧＦ１α测定，并与３０例正常人进行对照，发现：１；冠心病者ＴＸＢ２、６－Ｋ－ＰＧＦ１α及二者比值（Ｔ／６），均较正常人高，差异非常显著（Ｐ＜０．００１）；２．血栓组ＴＸＢ２明显升高，与无栓组差异非常显著（Ｐ＜０．００１），而二组间６－Ｋ－ＰＧＦ１α及Ｔ／６无明显差异（Ｐ＞０．０５）；３．血栓组治疗后，７７．７％微血栓消失，症状缓解，心电图正常或明显好转，血中ＴＸＢ２也明显下降，与治疗前相比有显著差异（Ｐ＜０．０１），而６－Ｋ－ＰＧＰ１α及Ｔ／６在治疗前后无明显差异。上述结果表明：１．冠心病微循环中微血栓的形成与其ＴＸＢ２显著升高密切相关。２．冠心病患者血中ＴＸＢ２浓度、微血栓与症状及心电图之间关系密切；小剂量肝素对血栓治疗效果明显，冠心病微血栓可作肝素治疗的明确指针。

Relationship Between Coronary Heart Disease with Microthrombus and Thromboxane B_2 and 6-Keto-Prostaglantin F_(1α)

Changes on bulbar conjunctiva microcirculation with 29 patients of coronary heart disease(CHD) were observed,among them,15 with microthrombus in microcirculation(treated with heparin),another 14 cases without it.Before and after treatment,29 patients were compored with 30 normal persons on thromboxane B2(TXB2) and 6-Keto-Prostaglantin F1α(6-K-PGF1α).The results showed:1.level of TXB2 and 6-K-PGF1α increased significantly in CHD patients compared with that in normal groups(P<0.001),2.level of TXB2 increased in CHD patients with microthrombus group compared with that in unmicrothrombus groups(P<0.001),3.after treatment with heparin,the level of TXB2 in microthrombus groups decreaed(P<0.01),4.there were closed relations among TXB2,microthrombus,clinical symptom and electrocardiogram.