Effect of lead on cardiac parasympathetic function |
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Authors: | Koji Teruya Haruhiko Sakurai Kazuyuki Omae Toshiaki Higashi Takashi Muto Yoko Kaneko |
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Institution: | (1) Department of Hygiene, School of Medicine, Kyorin University, 6-20-2 Shinkawa, 181 Mitaka-shi, Tokyo, Japan;(2) Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Japan;(3) Department of Health Policy and Management, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan |
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Abstract: | Summary A cross-sectional survey was performed on 172 male, lead exposed workers to clarify the effects of lead on the cardiac autonomic nervous system expressed as the decrease of R-R interval variation on an electrocardiogram and to obviate the dose-effect relationship between blood-lead level (Pb-B) and the degree of the decrease. For 132 workers who were exposed to lead for more than one year and whose Pb-B levels were relatively stable (Pb-B variation less than 20 g/dl during recent one year), a significant dose-related decrease of R-R interval variation during deep breathing was observed. Age-adjusted R-R interval variation during deep breathing in those whose Pb-B were 30 g/dl or above was significantly decreased compared with those whose Pb-B levels were 20 g/dl or below. This decrease was observed more clearly in younger workers. These results suggest that an effect on autonomic nervous system expressed as decrease of R-R interval variation during deep breathing might be one of the earliest effects of lead exposure. |
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Keywords: | Lead Autonomic nervous system R-R interval variation Electrocardiogram |
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