用模型方法研究心肌血流的时相分布及其灌注压依赖性

建立了一个适于研究左心室壁心肌血流动力学机制的仿真模型。其中考虑了三个有代表性的心肌壁内血管网，每个血管网由四个血管单元组成，各血管单元均由与生理状况较为发的非线性阻容元件模拟。仿真选用实测主动脉压和左心室腔压作为输入数据，结果表明，模型预测的总冠血流和透壁心肌灌注时相分布与现有结论较为一致。进而根据冠脉灌注的特点，了提高主动脉舒张压峰值对心肌灌注的影响，所得结果有助于解释临床采用主动脉内气囊反搏

Model-based Study of Time-dependent Coronary Blood Flow Distribution in Left Ventricular Wall and Its Dependences on Coronary Pressure Driving Force

The proposed model is of use for understanding the mechanism of intramyocardial circulation.There are three classical myocardial vascular nets in the model; each net has four vessel-size compartments whichare characterized by time--dependent nonlinear resistance and compliance. The experimentally measured timed-vary-ing perfusion and left ventricular pressure sources are used as driving inputs for the circulation. The phasic coroanry blood flow characteristics predicted by the model exhibit waveform patterns that correlate qualitatively with thegenerally accepted results. In addition, more work is made about the myocardial infusion which is essentially controlled by the coronary pressure driving foyce. The results make it clear that the intra-aortic balloon pumping andExternal counterpulsation are conducive to the balance between supply and demand of coronary blood flow.