| ^32磷—玻璃微球肝动脉灌注治疗肝肿瘤的毒副作用及并发症… |
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| 引用本文： | 李立 孙文豪. ^32磷—玻璃微球肝动脉灌注治疗肝肿瘤的毒副作用及并发症…[J]. 生物医学工程学杂志, 1997, 14(4): 376-379 |
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| 作者姓名： | 李立 孙文豪 |
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| 摘 要： | ＾３２磷－玻璃微球是一种新型内放射治疗药物。经对２４例晚期肝癌及３例多发性肝血和瘤病人初步临床应用结果表明：粒径４５－７５＾μ的＾３２Ｐ－ＧＭＳ也是治疗晚期肝癌安全有效的栓塞肝动脉灌注后无骨髓抑制，肾毒性和明显肝肺分流，肝功能指标多呈一过性改变，但肝吸收放射剂量〉５０Ｇｙ，微球量〉３ｇ时则出现严重消化道反应和明显肝功能损害，各种术后并发产增多。
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| 关 键 词： | 肝肿瘤 内放射疗法 玻璃微球 磷32 GMS |
The side effect and complication of intraarterial phosphorus-32 glass microspheres for patients with advanced hepatoma] |
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| L Li,L Yan,X Chen. The side effect and complication of intraarterial phosphorus-32 glass microspheres for patients with advanced hepatoma][J]. Journal of biomedical engineering, 1997, 14(4): 376-379 |
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| Authors: | L Li L Yan X Chen |
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| Affiliation: | Department of Surgery, First University Hospital, West China University of Medical Sciences, Chengdu 610041. |
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| Abstract: | The phosphorus-32 glass microspheres(32P-GMS) is a new radioembolizer for cancer therapy. From March 1994 to April 1995, 24 patients with unresectable hepatocellular carcinoma and 3 patients with cavernous hemangioma received internal radiation treatment of 32P-GMS. The clinical results demonstrated that hepatic arterial instillation of 32P-GMS appeared to be safe and effective for hepatocellular carcinoma. There was no significant bone marrow or renal toxicity or liver to pulmonary bypass. A transient change of liver function and fever occurred in almost all patients. Significant liver toxicity and gastrointestinal tract reaction were seen when radiation dose > 50 Gy or microspheres > 3 g, and then various postoperative complications occurred. |
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