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Anti-tumor action and clinical application of proteasome inhibitor
Authors:Yong-ming Zhou  Mei-xia Yu  Hui Long  Shi-ang Huang
Affiliation:[1]Department of hematology, The Affiliated Hospital, Wuhan University of Science and Technology, Wuhan 430000 [2]Stem Cell Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022
Abstract:Ubiquitin-proteasome pathway mediates the degradation of cell protein,and cell cycle,gene translation and expression,antigen presentation and inflammatory development.Proteasome inhibitor Call inhibit growth and proliferation of tumor cell,induce apoptosis and reverse multipledrug resistance of tumor cell,increase the sensitivity of other chemomerapeutic drugs and radiotherapy,and is a novel class of potent anti-tumor agents.
Keywords:Proteasome inhibitor  Ubiquitin-proteasome pathway  Tumor
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