Recombinant human G-CSF-mobilized peripheral blood stem cells for second allogeneic transplant after bone marrow graft rejection in children |
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| Authors: | Marco Zecca Cesare Perotti Pierluigi Marradi Daniela Montagna Giovanna Giorgiani RITA BALTER Luisella Prete & Franco Locatell i |
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| Institution: | Department of Paediatrics, University of Pavia, IRCCS Policlinico San Matteo, Pavia;;HLA-typing Laboratory, Immuno-Haematology and Transfusional Service, IRCCS Policlinico San Matteo, Pavia;and;;Department of Paediatrics, University of Verona, Italy |
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| Abstract: | Two children affected by severe aplastic anaemia and sickle cell anaemia rejected the allogeneic bone marrow transplantation from an HLA-matched unrelated volunteer and an HLA-identical sibling, respectively. In both cases a second transplant using granulocyte-colony stimulating factor (G-CSF) mobilized peripheral blood stem cells (PBSC) was performed. Donors were the HLA-haploidentical mother and the same HLA-identical sibling who was employed for the first marrow allograft, respectively. Treatment with G-CSF and PBSC collection were well tolerated. Both patients had engraftment of donor haemopoiesis and did not experience severe graft-versus-host disease. These cases confirm that PBSC transplant should be considered as a feasible treatment to reverse graft failure in paediatric patients. |
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| Keywords: | peripheral blood stem cells recombinant human granulocyte-colony stimulating factor graft rejection allogeneic bone marrow transplantation |
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