痰热清注射液联合大环内酯类药物治疗小儿支原体肺炎的系统分析

目的：系统评价痰热清注射液联用大环内酯类药物治疗小儿支原体肺炎的疗效。方法：计算机检索CNKI、CBM、VIP、Wangfang等数据库,检索时间为2000年至2013年,语种为中文,选择痰热清注射液联用大环内酯类药物为试验组与以单用大环内酯类药物为对照组治疗儿童支原体肺炎的随机对照试验,评价纳入的文献质量和提取有效数据后,采用RevMan5.0统计学软件进行Meta分析。结果：共纳入20项研究,合计2 151例患儿。Meta分析结果显示,试验组的临床有效率[OR=5.31,95%CI（3.71,7.60）,P〈0.01]、退热时间[MD=-1.55,95%CI（-1.83,-1.27）,P〈0.01]、咳嗽消失时间[MD=-2.45,95%CI（-2.86,-2.05）,P〈0.01]、肺部啰音消失时间[MD=-1.96,95%CI（-2.24,-1.68）,P〈0.01]、X线片恢复正常时间[MD=-2.49,95%CI（-3.31,-1.65）,P〈0.01]及平均住院时间[MD=-2.56,95%CI（-3.24,-1.88）,P〈0.01]均优于对照组,两组比较差异有统计学意义。结论：现有证据表明,痰热清注射液对小儿支原体肺炎有一定辅助治疗作用。

Systematic Analysis of Tanreqing Combined with Macrolide in the Treatment of Mycoplasma Pneumonia in Children

Objective： To systematic analysis the efficacy of Tanreqing combined with macrolide in the treatment of mycoplasma pneumonia in children. Methods： We searched clinical randomized controlled trials from 2000 to 2013 in CNKI,CBM,VIP and Wangfang database. The test group received Tanreqing combined with macrolide,and the control group received a single macrolide.After evaluation of the quality of included studies and extraction of data,Meta-analysis was performed by using RevMan5. 0 statistical software. Results： A total of twenty studies,including 2,151 cases of children were enrolled. Meta-analysis showed that the clinical efficacy of the test group [OR = 5. 31,95% CI（3. 71,7. 60）,P 〈0. 01],defervescence time [MD =- 1. 55,95% CI（- 1. 83,- 1. 27）,P 〈0. 01 ],cough disappearance time [MD =- 2. 45,95% CI（- 2. 86,- 2. 05）,P 〈 0. 01 ],pulmonary rales disappeared time [MD =- 1. 96,95% CI（- 2. 24,- 1. 68）,P 〈 0. 01],X-ray recovery time [MD =- 2. 49,95% CI（- 3. 31,- 1. 65）,P 〈 0. 01]and the average length of hospital stay [MD =- 2. 56,95% CI（- 3. 24,- 1. 88）,P 〈 0. 01] were all better than those of the control group; the difference between the two groups was statistically significant. Conclusions： Current evidence suggests that Tanreqing injection has good effect to children with mycoplasma pneumonia.