| 龙须草中1个新的二氢菲类化合物 |
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| 引用本文： | 李军,时圣明,孙玉坤,刘丽,孙云峰,范颖,张立德.龙须草中1个新的二氢菲类化合物[J].中草药,2015,46(16):2361-2364. |
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| 作者姓名： | 李军 时圣明 孙玉坤 刘丽 孙云峰 范颖 张立德 |
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| 作者单位： | 辽宁中医药大学基础医学院, 辽宁 沈阳 110032;辽宁中医药大学 省部共建中医脏象理论及应用教育部重点实验室, 辽宁 沈阳 110032;天津药物研究院, 天津 300193;武警辽宁省总队医院 药剂科, 辽宁 沈阳 110034;辽宁中医药大学基础医学院, 辽宁 沈阳 110032;辽宁中医药大学 省部共建中医脏象理论及应用教育部重点实验室, 辽宁 沈阳 110032;辽宁中医药大学基础医学院, 辽宁 沈阳 110032;辽宁中医药大学 省部共建中医脏象理论及应用教育部重点实验室, 辽宁 沈阳 110032;辽宁中医药大学基础医学院, 辽宁 沈阳 110032;辽宁中医药大学 省部共建中医脏象理论及应用教育部重点实验室, 辽宁 沈阳 110032;辽宁中医药大学 省部共建中医脏象理论及应用教育部重点实验室, 辽宁 沈阳 110032 |
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| 基金项目： | 中国博士后科学基金面上资助项目(2015M570257) |
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| 摘 要： | 目的研究龙须草Juncus setchuensis茎髓中的菲类化学成分。方法采用多种柱色谱方法分离纯化,通过理化性质及波谱分析技术鉴定化合物的结构。结果从龙须草茎髓的乙醇提取物中分离得到5个菲类化合物,分别鉴定为8-羟甲基-2-羟基-1-甲基-5-乙烯基-9,10-二氢菲(1)、4-ethenyl-9,10-dihydro-1,8-dimethyl-2,7-phenanthrenediol(2)、厄弗酚(3)、去氢厄弗酚(4)、4-ethenyl-9,10-dihydro-7-hydroxy-8-methyl-1-phenanthrenecarboxylic acid(5)。结论化合物1为未见文献报道的具有二氢菲类结构母核的新化合物,命名为龙须草醇A。
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| 关 键 词： | 龙须草 菲类化合物 灯芯草科 龙须草醇A 厄弗酚 |
| 收稿时间： | 6/9/2015 12:00:00 AM |
A new dihydrophenanthrene from Juncus setchuensis |
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| LI Jun,SHI Sheng-ming,SUN Yu-kun,LIU Li,SUN Yun-feng,FAN Ying and ZHANG Li-de.A new dihydrophenanthrene from Juncus setchuensis[J].Chinese Traditional and Herbal Drugs,2015,46(16):2361-2364. |
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| Authors: | LI Jun SHI Sheng-ming SUN Yu-kun LIU Li SUN Yun-feng FAN Ying and ZHANG Li-de |
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| Institution: | College of Basic Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China;Key Laboratory of TCM Viscera-State Theory and Applications, Coconstruction of Liaoning Province and Ministry of Education, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China;Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China;Department of Pharmacy, Liaoning Provincial Crops Hospital, Chinese People's Armed Police Force, Shenyang 110034, China;College of Basic Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China;Key Laboratory of TCM Viscera-State Theory and Applications, Coconstruction of Liaoning Province and Ministry of Education, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China;College of Basic Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China;Key Laboratory of TCM Viscera-State Theory and Applications, Coconstruction of Liaoning Province and Ministry of Education, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China;College of Basic Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China;Key Laboratory of TCM Viscera-State Theory and Applications, Coconstruction of Liaoning Province and Ministry of Education, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China;Key Laboratory of TCM Viscera-State Theory and Applications, Coconstruction of Liaoning Province and Ministry of Education, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China |
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| Abstract: | Objective To study the phenanthrenes from the pith of Juncus setchuensis. Methods The compounds were separated and purified by column chromatographies amd their structures were elucidated by physicochemical properties and spectroscopic methods. Results Five compounds were isolated from the 95% ethanol extract from the pith of J. setchuensis, their structures were determined as 8-hydroxymethyl-2-hydroxy-1-methyl-5-vinyl-9,10-dihydrophenanthrene (1), 4-ethenyl-9,10-dihydro-1,8-dimethyl-2,7-phenan-threnediol (2), effusol (3), dehydroeffusol (4), and 4-ethenyl-9,10-dihydro-7-hydroxy-8-methyl-1-phenanthrenecarboxylic acid (5). Conclusion Compound 1 is a new compound without literature report, named 8-hydroxymethyl-2-hydroxy-1-methyl-5-vinyl-9,10-dihydrophenanthrene. |
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| Keywords: | Juncus setchuensis Buchen phenanthrene Juncaceae setchuenol A effusol |
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