2种近缘中药翻白草和仙鹤草的化学成分和降血糖活性比较

翻白草Potentilla discolor和仙鹤草Agrimonia pilosa是蔷薇科(Rosaceae)2种近缘的药用植物,具有明确的降血糖活性,作为治疗糖尿病的中药材应用于临床。基于药用植物亲缘学(pharmaphylogeny)的理论,总结二者主要活性成分的生物合成途径,进而比较二者活性成分的共性及差异,并对物质基础与疗效之间的相关性进行总结。结果表明,2种近缘中药共有的生物合成途径占到60%,刺蒺藜苷、槲皮素等共有成分及翻白叶苷A、蔷薇酸等差异性成分同时也是活性成分,而特征成分及其量的差别可能引起功效及作用方式的不同。

Comparison on chemical components and hypoglycemic activities between two closely-related Chinese materia medica

Potentillae Discoloris cum Radice Herba and Agrimoniae Herba are closely-related medicinal plants in Rosaceae with specific hypoglycemic activities and applied as Chinese materia medica in clinical practice for the treatment of diabetes. Based upon pharmaphylogeny theories, the biosynthetic pathways of the principal active components of the above two Chinese herbs were summarized, and the commonness and differences of the active components were compared further and the correlation between material basis and curative effects was summarized as well. The results indicated that the common biosynthetic pathways of the two Chinese herbs accounted for 60%; The common components of tiliroside and quercetin, etc. as well as the differentiated components of potengriffioside A and rosolic acid, etc. are also the active components; The differences of the characteristic components and their contents may lead to the differences of functions and modes of action between the two Chinese herbs.