四苯硼钠滴定液浓度测量的不确定度评定

目的 对按中国药典2010年版第一增补本方法配制和标定的四苯硼钠滴定液(0.02 mol·L^-1)浓度进行不确定度评定。方法 通过对不确定度来源分析，建立测量模型，对标定过程中各不确定度的分量进行分析评估。结果 通过计算各变量的不确定度分量，得到本次标定浓度的相对标准不确定度为4.46×10^-3，合成标准不确定度为8.9×10^-5 mol·L^-1，扩展不确定度U=0.000 18 mol·L^-1，k=2。结论 建立了四苯硼钠滴定液浓度的测量不确定度评定方法，通过分析评估各分量不确定度的大小而明确测量不确定度的主要因素，优化实验条件使测定结果更加可靠准确。

Evaluation of Uncertainty for Concentration Calibration of (C6H5)4BNa Titration Solution

OBJECTIVE To evaluate for the uncertainty of the concentration of (C₆H₅)₄BNa (0.02 mol·L^-1) titration solution prepared and calibrated according to the method in the Chinese Pharmacopoeia first addition of the 2010 edition. METHODS According to the sources of uncertainty analysis, the measurement model was established and the various influencing factors in the calibration process was evaluated. RESULTS By calculating each fraction of uncertainty in various variable parameters, the relative standard uncertainty was 4.46×10^-3, the combined uncertainty was 8.9×10^-5, and the expanded uncertainty was 0.000 18 mol·L^-1, k=2. CONCLUSION The method of the uncertainty evaluation for calibrating the concentration of (C₆H₅)₄BNa titration solution is established. The more reliable results of the measurement could be obtained when the measure was optimized by magnitude analysis all uncertainty.