| 白僵蚕化学成分研究 |
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| 引用本文： | 黄居敏,邓华勇,蔡英,李旸,张普照,杨明.白僵蚕化学成分研究[J].中草药,2015,46(16):2377-2380. |
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| 作者姓名： | 黄居敏 邓华勇 蔡英 李旸 张普照 杨明 |
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| 作者单位： | 江西中医药大学 现代中药制剂教育部重点实验室, 江西 南昌 330004;江西省南城县人民医院 药剂科, 江西 南城 344700;江西中医药大学 现代中药制剂教育部重点实验室, 江西 南昌 330004;江西中医药大学 现代中药制剂教育部重点实验室, 江西 南昌 330004;江西中医药大学 现代中药制剂教育部重点实验室, 江西 南昌 330004;江西中医药大学 现代中药制剂教育部重点实验室, 江西 南昌 330004 |
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| 基金项目： | 江西省卫生厅项目(2014A005) |
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| 摘 要： | 目的研究白僵蚕Bombyx Batryticatus的化学成分。方法利用正相硅胶柱色谱、Sephadex LH20、反相硅胶柱色谱及反相制备液相色谱等手段进行分离纯化,并通过1H-、13C-NMR等波谱技术进行结构鉴定。结果从白僵蚕醋酸乙酯层中分离得到11个化合物,分别鉴定为环(D-脯-D-缬)二肽(1)、环(S-脯-R-亮)二肽(2)、环(D-脯-D-异亮)二肽(3)、环(D-脯-D-苯丙)二肽(4)、金色酰胺醇酯(5)、(+)-松脂醇(6)、异黑麦草内酯(7)、butyl-2-pyrrolidone-5-carboxylate(8)、(-)-杜仲树脂酚(9)、(-)-落叶松树脂醇(10)、4-羟基苯乙酸甲酯(11)。结论所有化合物均为首次从僵蚕中分离得到。
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| 关 键 词： | 白僵蚕 环肽类化合物 木脂素类化合物 环(D-脯-D-缬)二肽 金色酰胺醇酯 (-)-杜仲树脂酚 |
| 收稿时间： | 2015/4/22 0:00:00 |
Chnemical constituents from Bombyx Batryticatus |
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| HUANG Ju-min,DENG Hua-yong,CAI Ying,LI Yang,ZHANG Pu-zhao and YANG Ming.Chnemical constituents from Bombyx Batryticatus[J].Chinese Traditional and Herbal Drugs,2015,46(16):2377-2380. |
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| Authors: | HUANG Ju-min DENG Hua-yong CAI Ying LI Yang ZHANG Pu-zhao and YANG Ming |
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| Institution: | Key Laboratory Modern Preparation of TCM, Ministry of Education, Jiangxi University of TCM, Nanchang 330004, China;Pharmaceutical Preparation Section, Nancheng People's Hospital of Jiangxi Province, Nancheng 344700, China;Key Laboratory Modern Preparation of TCM, Ministry of Education, Jiangxi University of TCM, Nanchang 330004, China;Key Laboratory Modern Preparation of TCM, Ministry of Education, Jiangxi University of TCM, Nanchang 330004, China;Key Laboratory Modern Preparation of TCM, Ministry of Education, Jiangxi University of TCM, Nanchang 330004, China;Key Laboratory Modern Preparation of TCM, Ministry of Education, Jiangxi University of TCM, Nanchang 330004, China |
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| Abstract: | Objective To study the chemical constituents of Bombyx batryticatus. Methods The chemical constituents of B. batryticatus were isolated by different column chromatographic techniques, including silica gel and Sephadex LH-20 columns. The structures of these compounds were identified by a comprehensive analysis of the spectroscopic data. Results Eleven compounds were isolated from the EtOAc extract of B. batryticatus. The compounds were identified as cyclo (D)-Pro-(D)-Val (1), cyclo (S)-Pro-(R)-Leu (2), cyclo (D)-Pro-(D)-Ile (3), cyclo (D)-Pro-(D)-Phe (4), aurantiamid (5), (+)-pinoresinol (6), isololiolide (7), butyl-2-pyrrolidone-5-carboxylate (8), (-)-medioresinol (9), (-)-lariciresinol (10), and methylphydroxybenzeneacetate (11). Conclusion All the compounds are isolated from B. batryticatus for the first time. |
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| Keywords: | Bombyx Batryticatus cyclopeptides lignans cyclo (D)-Pro-(D)-Val aurantiamid (-)-medioresinol |
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