乳腺肿瘤癌基因c—erbB—2,c—myc的表达及其临床意义

应用免疫组织化学方法，研究６１例乳腺良、恶性病变ｃ－ｅｒｂＢ－２、ｃ－ｍｙｃ的癌基因的表达情况。４６例乳腺癌中ｃ－ｅｒｂＢ－２和ｃ－ｍｙｃ阳性率分别为５０％（２３／４６）和４５．７％（２１／４６）１５例乳腺良性病变中阳性率分别为６．７％（１／１５）和５３．５％（８／１５）。

c-erbB-2,c-myc oncogene expression in human breast neoplasm and its clinical significance

Using immunohistochemical method, we examinated the expression of c-erbB-2 and c-myc oncogene in 61 cases of humanbreast benign and melignant diseases. The positive rates of c-erbB-2 and c-myc were 50% (23/46) and 45. 7 % (21 /46) respectively in 46 cases of breast cancer, while those were 6. 7 % (1 /15 ) and 53. 5 %,(8 /15 ) respectively in breast benign diseases. It indicated that c-erbB-2 may be helpful to differential diagnosis of breast benign and malignant diseases. It was particularly useful for diagnosis of invasive ductal breast carcinoma,medullary breast carcinoma and that with axillary lymphnode metastasis. In .addition,it indicated that the c-myc expression was not useful for (lifferential diagnosis of benign and malignant breast diseases and no statistical difference was found between c-myc expression and many clinicopathological factors.