| 阻塞性睡眠呼吸暂停综合征动物模型的建立方法 |
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| 作者姓名： | Yang L Hu Y Zhang X |
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| 作者单位： | 广州医学院第一附属医院耳鼻咽喉头颈外科 |
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| 摘 要： | 阻塞性睡眠呼吸暂停综合征(OSAS)因其高发病率和对人体多个系统的严重危害,已成为近年来多学科研究的热点。英格兰牛头犬(Englishbulldog)〔1〕、中国广西陆川猪〔2〕及最近发现的新西兰肥胖的(New Zealand obese)小鼠〔3〕这些自发性OSAS动物模型由于来源相对困难,不可能大量应
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| 关 键 词： | 阻塞性睡眠呼吸暂停综合征 低氧血症 高碳酸血症 上气道阻塞 睡眠紊乱 动物模型 |
An animal model of obstructive sleep apnea syndrome |
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| Yang L,Hu Y,Zhang X.An animal model of obstructive sleep apnea syndrome[J].Journal of Clinical Otorhinolaryngology,2012,26(12):569-572. |
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| Authors: | Yang Lei Hu Yingjie Zhang Xiaowen |
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| Abstract: | Obstructive sleep apnea syndrome (OSAS) is endangering human health seriously now. We had reviewed some typical animal model which had at least one OSAS character of intermittent hypoxia and/or hypercapnia, upper airway obstruction and sleep structure disorder. However, all of these models could not simulate clinical and pathological features of OSAS completely. Establishing a suitable animal model to study OSAS and related diseases is very important. |
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| Keywords: | obstructive sleep apnea syndrome hypoxia hypercapnia upper airway obstruction sleep disorder animal model |
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