The use of polymeric platinum(IV) prodrugs to deliver multinuclear platinum(II) drugs with reduced systemic toxicity and enhanced antitumor efficacy |
| |
| Authors: | Haihua Xiao Haiqin Song Yu Zhang Ruogu Qi Rui Wang Zhigang Xie Yubin Huang Yuxin Li Yin Wu Xiabin Jing |
| |
| Affiliation: | State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, People's Republic of China; Graduate School of Chinese Academy of Sciences, Beijing 100049, People's Republic of China. |
| |
| Abstract: | Two dinuclear platinum(IV) prodrugs were prepared from cisplatin and oxaliplatin, and tethered to amphiphilic biodegradable block copolymers. The polymeric dinuclear platinum(IV) prodrugs were allowed to self-assemble into nanomicelles, which showed reduced systemic toxicity, relatively long blood circulation, and enhanced antitumor efficacy. In this way, the bottleneck of present multinuclear platinum drugs, especially their severe systemic toxicity, might be overcome. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
