| Effect of SR-140333,a neurokinin-1 receptor antagonist,on airway reactivity to methacholine in sedated rats |
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| 引用本文： | 田炯,魏尔清,陈积愫,张纬萍. Effect of SR-140333,a neurokinin-1 receptor antagonist,on airway reactivity to methacholine in sedated rats[J]. Acta pharmacologica Sinica, 1997, 0(6) |
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| 作者姓名： | 田炯 魏尔清 陈积愫 张纬萍 |
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| 作者单位： | 浙江医科大学 |
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| 摘 要： | 目的：探讨神经激肽对乙酰甲胆碱（ＭＣ）气道反应性的作用．方法：观察非肽类ＮＫ１受体拮抗剂ＳＲ１４０３３３对镇静大鼠的ＭＣ气道反应性和离体气管条的收缩反应．结果：ＳＲ１４０３３３抑制ＭＣ气雾（１０－１０００μｍｏｌ／ｍ３）引起的呼吸频率增快，抑制ＭＣ气雾（１ｍｍｏｌ／ｍ３）反应的ＩＤ５０为４９（１４－１７２μｇ·ｋｇ－１）；ＳＲ１４０３３３１μｍｏｌ·Ｌ－１对乙酰甲胆碱引起的气管平滑肌收缩无抑制作用．阿托品可阻断ＭＣ的在体和离体反应．结论：内源性速激肽参与在体ＭＣ气道反应，至少部分由ＮＫ１受体介导．
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| 关 键 词： | SR-140333；氯醋甲胆碱；阿托品；神经激肽-1受体；沙丁胺醇；氨茶碱；地塞米松；气管 |
Effect of SR 140333, a neurokinin 1 receptor antagonist, on airway reactivity to methacholine in sedated rats |
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| TIAN Jiong ,WEI Er Qing ,,CHEN Ji Su ,ZHANG Wei Ping. Effect of SR 140333, a neurokinin 1 receptor antagonist, on airway reactivity to methacholine in sedated rats[J]. Acta pharmacologica Sinica, 1997, 0(6) |
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| Authors: | TIAN Jiong WEI Er Qing CHEN Ji Su ZHANG Wei Ping |
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| Affiliation: | TIAN Jiong 2,WEI Er Qing 2,3,CHEN Ji Su 2,ZHANG Wei Ping 2 |
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| Abstract: | |
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| Keywords: | SR 140333 methacholine chloride atropine neurokinin 1 receptors albuterol amino-phylline dexamethasone trachea |
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