| 原发性肥厚型心肌病与HLA-DQ的相关性研究 |
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| 引用本文： | 张修武,张之炯,郭迅,郭兆贵.原发性肥厚型心肌病与HLA-DQ的相关性研究[J].现代免疫学,1997(1). |
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| 作者姓名： | 张修武 张之炯 郭迅 郭兆贵 |
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| 作者单位： | 湖南医科大学分子药理研究室 长沙410078
(张修武，张之炯，郭迅)，湖南医科大学分子药理研究室 长沙410078(郭兆贵) |
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| 基金项目： | 国家自然科学基金资助项目NO:39370310 |
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| 摘 要： | 本文用PCR/SSO方法对41例原发性肥厚型心肌病患者和52例正常人HLA-DQA1和DQB1基因的多态性进行分析.发现,在肥厚型心肌病患者中,DQA1＊0201,DQB1＊0504,0502等位基因频率明显较低,其相对风险值分别为9.51、5.87和11.60;而DQA1*0501,DQB1＊03031的频率明显地高,相对风险值分别为2.93和6.65.初步认为,原发性肥厚型心肌病与某些HLA-DQ基因相关联.
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| 关 键 词： | 原发性肥厚型心肌病 HLA-DQ |
The Study on the Association Between the Hypertrophic Cardiomyopathy and HLA-DQ |
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| Zhang Xiuwu,Zhang Zhijiong,Guo Xun,Guo Zhaogui.The Study on the Association Between the Hypertrophic Cardiomyopathy and HLA-DQ[J].Current Immunology,1997(1). |
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| Authors: | Zhang Xiuwu Zhang Zhijiong Guo Xun Guo Zhaogui |
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| Abstract: | Using PCR/SSO technique, we analyzed DQA1 and DQB1 polymorphisms in 41 patients with hypertrophic cardiomyopathy and 52 healthy HANs. The results showed that the alleles frequencies of DQAl * 0201, DQB1 * 0502, 0504 were signifi-cantly lower in hypertrophic cardiomyopathy patients as compared with those in the normal controls with a relative risk value of 9.51, 5.87 and 11.60 respectively; While the alleles frequencies of DQAl * 0501, DQB1 * 03031 were considerably increased in hypertrophic cardiomyopathy patients as compared with those in the normal controls with a relative risk value of 2.93 and 6.65 respectively, These results suggested that hypertrophic cardiomyopathy is associated with HLA-DQ gene. |
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| Keywords: | hypertrophic cardiomyopathy HLA-DQ DQAl DQBl association |
| 本文献已被 CNKI 等数据库收录！ |
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