血清趋化因子检测在肺癌早期诊断中的应用价值

目的探讨血清趋化因子检测在肺癌早期诊断中的应用价值。方法采用回顾性总结研究方法,选择肺癌患者72例(肺癌组)、肺炎患者72例(肺炎组)与健康人72例(对照组),检测3组人群的白细胞计数,检测血清趋化因子MIP-3α、IL-8、Fractalkine水平,随访记录患者的预后,判断诊断价值。结果肺癌组与肺炎组的外周白细胞计数均显著低于对照组(P<0.05),但肺癌组与肺炎组对比差异无统计学意义(P>0.05)。肺癌组与肺炎组的血清MIP-3α、IL-8、Fractalkine水平都高于对照组(P<0.05),肺癌组高于肺炎组(P<0.05)。随访至2018年9月,肺癌组中患者死亡6例,存活66例,死亡率为8.3%。多因素logistic回归分析淋巴结转移、临床分期、组织学分化、MIP-3α、IL-8、Fractalkine为影响患者预后死亡的主要独立危险因素(P<0.05)。结论MIP-3α、IL-8、Fractalkine等趋化因子联合现有的肿瘤标志物,可用于诊断早期肺癌与预测预后。

Application Value of Serum Chemokine Detection in the Early Diagnosis of Lung Cancer

Objective To investigate the values of serum chemokine detection in the early diagnosis of lung cancer.Methods Used a retrospective summary study method,72 patients with lung cancer diagnosed(lung cancer group),72 patients with pneumonia(pneumonia group)and 72 healthy people(control group)were selected.The white blood cell counts of the 3 groups were measured,and the levels of serum chemokines-MIP-3α,IL-8,and Fractalkine were measured.The prognosis of the patients were recorded and the diagnostic values were judged.Results The peripheral white blood cell counts of the lung cancer group and the pneumonia group were significantly lower than those of the control group(P<0.05),there were no significant difference compared between the lung cancer group and the pneumonia group(P>0.05).The levels of serum MIP-3α,IL-8 and Fractalkine in the lung cancer group and the pneumonia group were higher than those of the control group(P<0.05),and the lung cancer group were higher than the pneumonia group(P<0.05).Follow-up was conducted until September 2018,6 patients died in the lung cancer group,66 patients survived,and the mortality rate was 8.3%.Multivariate logistic regression analysis of lymph node metastasis,clinical stage,histological differentiation,MIP-3α,IL-8,and Fractalkine were the main independent risk factors for the prognosis of patients(P<0.05).Conclusion MIP-3α,IL-8,Fractalkine and other chemokines can be combined with existing tumor markers,which can be used to diagnose early lung cancer and predict prognosis.