丹参多酚酸联合血塞通注射液治疗急性脑梗死临床研究

目的研究丹参多酚酸联合血塞通注射液治疗急性脑梗死的临床疗效及对患者微栓子(MES)、炎性因子与颈动脉硬化斑块的影响。方法选取医院2016年4月至2018年4月收治的急性脑梗死患者116例,按随机数字表法分为对照组和治疗组,各58例。两组患者均予常规治疗,治疗组患者加用注射用丹参多酚酸和血塞通注射液,均连续治疗2周。结果治疗组总有效率为96. 55%,明显高于对照组的77. 59%(P <0. 05);治疗后,治疗组存在MES例数明显少于对照组,颈动脉内膜斑块面积及内-中膜厚度(IMT)和不稳定性斑块检出率明显低于对照组(P <0. 05);治疗后,两组患者的超敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)水平均明显降低,且治疗组明显低于对照组(P <0. 05);治疗组与对照组不良反应发生率相当(6. 90%比8. 62%,P> 0. 05)。结论丹参多酚酸联合血塞通注射液治疗急性脑梗死,可明显减少MES和颈动脉硬化斑块,降低炎性因子水平。

Salvia Miltiorrhiza Polyphenolic Acid Combined with Xuesaitong Injection in Treating Acute Cerebral Infarction

Objective To study the clinical efficacy of Salvia miltiorrhiza polyphenolic acid combined with Xuesaitong Injection in the treatment of patients with acute cerebral infarction and its effects on the patients’ micro embolus( MES),inflammatory factors and carotid atherosclerosis plaque. Methods A total of 116 cases of acute cerebral infarction patients in the hospital from April 2016 to April2018 were selected and divided into the control group and the treatment group by the random number table method,58 cases in each group. Both groups were treated with clinical routine method,while the treatment group was added with Salvia miltiorrhiza polyphenolic acid combined with Xuesaitong Injection. The two groups were continuously treated for 2 weeks. Results The clinical effective rate of routine group was 96. 55%,which was significantly higher than 77. 59% of the control group( P < 0. 05). After treatment,the number of MES cases in the treatment group was significantly lower than that in the control group( P < 0. 05);the detection rate of carotid intima plaque area,intima-media thickness( IMT) and unstable plaque in the treatment group was significantly lower than that in the control group( P < 0. 05);the levels of high-sensitivity C-reactive protein( hs-CRP),interleukin 6( IL-6),and tumor necrosis factor-α( TENF-α) in the two groups were significantly reduced,and the levels in the treatment group was significantly lower than those of the control group( P < 0. 05). The incidence of adverse reactions was similar in the treatment group and the control group( 6. 90%vs. 8. 62%,P > 0. 05). Conclusion Salvia miltiorrhiza polyphenolic acid combined with Xuesaitong Injection has good clinical efficacy on acute cerebral infarction patients,which can significantly reduce the number of MES cases,carotid atherosclerotic plaques and inflammatory factors.