长链非编码RNA BCAR4在弥漫性大B细胞淋巴瘤患者中的表达及其临床意义

目的探讨长链非编码RNA(LncRNA)BCAR4在弥漫性大B细胞淋巴瘤(DLBCL)患者中的表达及其临床意义。方法以90例DLBCL患者为观察组,以同期90例淋巴反应性增生(RLH)患者为对照组。采用实时荧光定量PCR(QRT-PCR)检测2组血液LncRNA BCAR4含量,并分析其与DLBCL病理特征及患者预后的关系。结果DLBCL患者血清BCAR4表达水平(4.25±0.23)明显高于RLH患者(1.12±0.07)(P<0.05)。肿瘤较大、分期较高、存在B症状、国际预后指数(IPI)较高的DLBCL患者LncRNA BCAR4表达水平明显更高(P<0.05);高表达lncRNA BCAR4的DLBCL患者中位无进展生存时间(16.15±2.24个月)显著短于低表达者(33.06±3.22个月)(P<0.05)。多因素Cox回归分析显示,高表达的lncRNA BCAR4与高IPI指数是DLBCL患者预后不良的独立危险因素(P<0.05)。结论lncRNA BCAR4在DLBCL患者中表达水平较高,并与患者的肿瘤大小、分期、是否存在B症状、IPI指数及预后有关。

Expression of Long-chain Non-coding RNA BCAR4 in Patients with Diffuse Large B-cell Lymphoma and Its Clinical Significance

Objective To investigate the expression and clinical significance of long-chain non-coding RNA(LncRNA)BCAR4 in patients with diffuse large B-cell lymphoma(DLBCL).Methods 90 patients with DLBCL were enrolled in the observation group.90 patients with lymphatic reactive hyperplasia(RLH)were enrolled in the control group.The blood LncRNA BCAR4 content of the two groups were detected by Real-time quantitative PCR(QRT-RCP),and its relationship with pathological features and prognosis of patients with DLBCL were analysised.Results The serum BCAR4 expression level of patients with DLBCL(4.25±0.23)was significantly higher than that of RLH patients(1.12±0.07)(P<0.05).The patients with DLBCL whose tumor size was larger,the stage was higher,there were B symptoms,and the international prognostic index(IPI)was higher,the expression level of LNCRNA BCAR4 was significantly higher(P<0.05).The median progression-free survival time of DLBCL patients with high expression(16.15±2.24 months)of lncRNA BCAR4 was significantly lower than that of low-expression patients(33.06±3.22 months)(P<0.05);Multivariate Cox regression analysis showed that high expression of lncRNA BCAR4 and high IPI index were independent risk factors for poor prognosis in patients with DLBCL(P<0.05).Conclusion lncRNA BCAR4 is highly expressed in patients with DLBCL and is associated with tumor size,stage,presence or absence of B symptoms,and high IPI index.