血管内皮生长因子与乳腺癌临床病理因素及预后的关系

目的：探讨血管内皮生长因子在乳腺癌中的表达情况及其与预后的关系。方法：采用免疫组化法对1985年至1986年手术治疗的109例乳腺癌的原发灶进行血管内皮生长因子（VEGF）和微血管密度（MVD）检测，并与临床病理资料进行比较分析。结果：VEGF强表达组淋巴结转移率（52．2％）和病理分级明显高于弱表达且（23．5％，P＜0．05）；随VEGF表达强度的增加，生存率（5年、10年、15年）呈下降趋势，但无明显差异；VEGF与肿瘤大小、绝经状况、雌孕激素受体之间未见相关性。结论：VEGF表达与乳腺癌淋巴结转移和病理分级呈正相关，与预后呈负相关趋势，是估计恶性程度的有用指标，对判断预后有参考价值。

Relationship between the VEGF and pathological factor as well as prognostic significance in breast cancer

Objective: To investigate the expression of vascular endothelial growth factor (VEGF) in breast cancer and to evaluate the prognostic significance of VEGF.Methods: A total of 109 patients were selected to this study from the years l985 to l986. VEGF and microvessel density(MVD) were analyzed by immunohistochemistry in primary lesions in these patients. Resu1ts: High expression group of VEGF and low expression group of VEGF had significant difference in lymph node involvement(52.2% and 23.5%, P<0.05) and histologic grade. There was a trend of increase of expression level of VEGF compared with decrease of 5-years 10-years 15-years survival but which hadn't significant difference.VEGF expression is not connected with tumor size,menopause and estrogen receptor. Conclusion: VEGF expression is significantly related to the lymph node involvement and histologic grade and may be used as one of the prognostic indicators in breast cancer.