HDMF在大鼠体内代谢动力学的实验观察

Pharmgcokinetics of HDMF in Rats

This paper reports the pharmacokinetics of HDMF in rats after single oral administration. The biological samples were detected by high performance liquid chromatography. The con- centration-time data were fitted by using a practical pharma- cokinetic program(3P87), t1/2=5. 013h,t_(peak)=0. 477h.c_(max)= 40.520ug/ml,Cl=0.165L. kg~1.h~1,V_d=1. 190L/kg. The result showed that HDMF was absorbed rapid in rat .and elim- inition also was quick, t_(peak)(1.0844b) in rat liver was shorter. C_(max)(46. 6466ug) was higher. The concentration in liver was more than those in other tissues. The excreted amount from urine and faeces was very small ,and the accumutated amount for 24h was only 6.87%. Origmat shape of HDMF from urine after 24h was not fount, it showed that most HDMF had been decomposited or been transformed into other chemical com- pound in rat.