| 肺癌血清肿瘤标记物的联合检测及其临床意义 |
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| 引用本文： | 熊石龙,王前,郑磊,包杰.肺癌血清肿瘤标记物的联合检测及其临床意义[J].热带医学杂志,2009,9(8). |
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| 作者姓名： | 熊石龙 王前 郑磊 包杰 |
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| 作者单位： | 南方医科大学南方医院检验医学中心,广州,510515 |
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| 基金项目： | 广东省自然科学基金(No.07300312,8451051501000580) |
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| 摘 要： | 目的评价CEA、NSE、CYFRA21-1联合检测对肺癌与良性肺部疾病鉴别诊断的价值。方法应用电化学发光法(ECLIA)检测经病理确诊的56例肺癌、41例良性肺部疾病和30例正常体检者血清中癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)和细胞角蛋白21-1(CYFRA21-1)的含量。结果肺癌组CEA、NSE、CYFRA21-1测定水平明显高于肺良性病变组和正常对照组,差异具有统计学意义(P<0.05);CEA、NSE、CYFRA21-1对肺癌的敏感性分别为51.79%、44.64%、55.36%,特异性分别为92.96%、90.14%、88.73%;CEA、NSE、CYFRA21-1三项联合检测对肺癌的敏感性与特异性分别为92.86%和94.37%。结论CEA、NSE、CYFRA21-1三项肿瘤标记物联合检测明显提高肺癌诊断的阳性率,有助于肺癌的预测和鉴别诊断。
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| 关 键 词： | CEA NSE CYFRA21-1 联合检测 肺癌 |
Clinical Significance of Combined Detection of Serum Tumor Markers in Lung Cancer Patients |
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| XIONG Shi-long,WANG Qian,ZHENG Lei,BAO Jie.Clinical Significance of Combined Detection of Serum Tumor Markers in Lung Cancer Patients[J].Journal Of Tropical Medicine,2009,9(8). |
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| Authors: | XIONG Shi-long WANG Qian ZHENG Lei BAO Jie |
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| Institution: | Laboratory Medicine Center;Nanfang Hospital;Southern Medical University;Guangdong;Guangzhou 510515;China |
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| Abstract: | Objective To explore the clinical application of serum CEA,NSE and CYFRA21-1 markers in diagnosis of patients with lung cancer.Method Serum levels of CEA,NSE and CYFRA21-1 were determined by electrochemiluminescence(ECLIA)in 56 patients with lung cancer,41 patients with benign lungs diseases and 30 normal subjects.Result The serum levels of CEA,NSE and CYFRA21-1 were markedly elevated in patients with lung cancer than those with benign lung diseases and healthy subjects(P<0.05).The sensitivity of CEA,NSE an... |
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| Keywords: | CEA NSE CYFRA21-1 combined detection lung cancer |
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