Comparative cytotoxicity of 2,3,9-trimethoxypterocarpan in leukemia cell lines (HL-60, Jurkat,Molt-4, and K562) and human peripheral blood mononuclear cells |
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| Authors: | Gardenia C. G. Militão Daniel P. Bezerra Claudia Pessoa Manoel Odorico de Moraes Flavio A. F. da Ponte Mary Anne S. Lima Edilberto R. Silveira Letícia V. Costa-Lotufo |
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| Affiliation: | 1.Curso de Pós-Gradua??o em Farmacologia, Departamento de Fisiologia e Farmacologia, Faculdade de Medicina,Universidade Federal do Ceará,Fortaleza,Brazil;2.Curso de Pós-Gradua??o em Química Organica, Departamento de Química Organica e Inorganica, Centro de Ciências,Universidade Federal do Ceará,Fortaleza,Brazil |
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| Abstract: | The purpose of this study was to investigate the antiproliferative activity of 2,3,9-trimethoxypterocarpan, a known pterocarpan with cytotoxic activity against many tumor cell lines, in a panel of four leukemia cell lines (HL-60, Molt-4, Jurkat, and K562) and on human peripheral blood mononuclear cells (PBMC). The pterocarpan showed IC50 ranging from 0.1 to 0.5 μg/ml at leukemic cells after 72 h of incubation, with K562 being the most resistant cell line. This compound seemed to be selective to tumor cell lines, since at a concentration of 10 μg/ml after 72 h, it only reduced 19% of viable peripheral mononuclear cells. |
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| Keywords: | 2,3,9-trimethoxypterocarpan Leukemia cells PBMC |
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