丹红注射液治疗血管性痴呆的临床疗效及机制探讨

目的观察丹红注射液治疗血管性痴呆的临床疗效和安全性，并探讨其作用机制。方法血管性痴呆患者130例，随机分为丹红注射液治疗组和金纳多对照组，每组65例。在基础药物治疗基础上，分别给予丹红注射液（40ml／d），金纳多注射液（20ml／d）静脉滴注，连续4周。治疗前后由专人进行简易精神状态量表（MMSE）、临床痴呆量表（CDR）及全面衰退量表（GDS）的评定。结果实验组及对照组治疗4周后，MMSE、CDR评分均较治疗前均显著提高，GDS评分显著降低。结论丹红注射液较金纳多注射液可能更显著改善患者的认知功能和痴呆程度。其治疗血管性痴呆的机制可能与其改善冠脉循环，减少脑缺血，抑制血栓形成有关。

Clinical effect of Dan Hong injection on patients with vascular dementia

Objective To observe the clinical effect and safety of the Dan Hong injection on the patients with vascular dementia. Methods 130 patients with VD were randomly divided into treatment group and control group （65 patients each）. Patients in the treatment group were treated with Dan Hong injection in a dose of 40 ml per day for 4 weeks, and patients in the control treatment were treated with ginaton injection solution in a dose of 20 ml per day for 4 weeks. Before and after treatment, the mini mental status examination （MMSE）, clinical dementia rate （CDR） and global deterioate scale （GDS） were measured by the same doctor. Results 4 weeks after treatment, MMSE and CDR were elevated, and GD$ was decreased in both groups. Conclusions Both Dan Hong and ginaton injection solutionis are safe in treatment of VD. And the effect of Dan Hong injection is better than ginaton injection solutions. Improving the coronary circulation, reducing cerebral ischemia, and inhibiting thrombosis maybe play important roles in the treatment of VD by Dan Hong injection.