| 尿多酸肽对乳腺癌细胞增殖的抑制作用 |
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| 引用本文： | 王艳红,郑伟.尿多酸肽对乳腺癌细胞增殖的抑制作用[J].中国临床药理学与治疗学,2005,10(6):677-681. |
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| 作者姓名： | 王艳红 郑伟 |
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| 作者单位： | 1. 解放军总医院第一临床药局,北京,100853
2. 解放军总医院,普外科,北京,100853 |
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| 摘 要： | 目的:研究尿多酸肽(CDAII)对乳腺癌细胞增殖的抑制作用。方法:将CDAII与乳腺癌细胞株MCF7和MDAMB231进行体外培养,观察CDAII对乳腺癌细胞生长曲线及形态学等方面的影响。结果:CDAII对两种不同生物特征的乳腺癌细胞株ER MCF7细胞和ER-MDAMB231细胞生长和增殖均有不同程度的抑制作用,而且其生长抑制作用在一定时间和剂量范围内,呈剂量依赖性;形态上,加CDAII培养后,细胞体积增大,生长密度稀疏,细胞间隙拉宽,胞质增多,核质比例下降,核仁小而少,细胞固缩、退变。结论:CDAII可抑制不同生物学特性的两株乳腺癌细胞的生长和增殖。
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| 关 键 词： | 乳腺癌 尿多酸肽(CDA-II) 维甲酸 细胞培养 |
| 文章编号： | 1009-2501(2005)06-0677-05 |
| 修稿时间： | 2005年5月31日 |
Effects of uroacitides on proliferation ability of breast cancer cells |
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| WANG Yan-hong,ZHENG Wei.Effects of uroacitides on proliferation ability of breast cancer cells[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2005,10(6):677-681. |
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| Authors: | WANG Yan-hong ZHENG Wei |
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| Institution: | WANG Yan-hong,ZHENG Wei The First Clinical Medicine Bureau,Department of General Surgery,General Hospital of Chinese PLA,Beijing 100853,China |
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| Abstract: | AIM: To investigate the growth inhibition effects of CDA-II on breast cancer cells. METHODS: The effects of CDA-II on growth curve and morphology of breast carcinoma cell lines MCF-7 and MDA-MB-231 were observed in vitro cultures. RESULTS: CDA-II reduced the growth speed and proliferation ability. CONCLUSION: CDA-II has remarkable effects on anti-cell-proliferation and shows good prospects of application in the treatment of patients with breast carcinoma. |
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| Keywords: | breast carcinoma uroacitides (CDA-II) retinoic acid cell culture |
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