老年性黄斑变性的吲哚青绿和荧光素眼底血管造影

目的 探讨眼底荧光素血管造影(fundus fluorescein angiography,FFA)和吲哚青绿血管造影(indocyanine green angiography,ICGA)在老年性黄斑变性(age-related macular degeneration,AMD)患者中的临床应用.方法 对AMD患者375例742只眼的FFA和ICGA检查资料进行分析总结.结果 在所有患者中,萎缩型504只眼(67.9%),渗出型238只眼(32.1%).在同步进行FFA和ICGA检查的渗出型AMD93只眼中,FFA检查发现典型性CNV 14只眼(15.1%),隐匿性CNV 79只眼(84.9%);ICGA检查发现边界清楚的CNV48只眼(51.6%),两者相比差异具有统计学意义(x2=27.97,P＜0.01).ICGA检查发现CNV的供养血管6只眼(6.5%),均位于中心凹旁或中心凹外.在发现边界清楚CNV的48只眼中,中心凹下CNV29只眼(60.4%),中心凹旁CNV 12只眼(25.0%),中心凹外CNV7只眼(14.6%).结论 与FFA相比,ICGA可以更加准确地显示CNV,发现CNV的供养血管,对AMD的临床诊断和治疗具有更重要的指导意义.

Indocyanine green and fundus fluorescein angiography in age-related macular degeneration

Objective To investigate the clinical application of fimdus fluorescein angiography(FFA) and indocyanine green angiography(ICGA)in age-related macular degeneration(AMD). Methods The FFA and ICGA data of 742 eyes of 375 AMD patients were analyzed and summarized.Restflts In all patients, 504 eyes (67.9%) were atrophic AMD and 238 eyes (32.1%)were exudative AMD. Of 93 exudative AMD eyes simultaneously performed FFA and ICGA, 14 eyes (15.1%)with classic CNV and 79 eyes (84.9%) with occult CNV were found by FFA, 48 eyes (51.6%)with clear boundary CNV were found by ICGA, and there was significantly statistical difference (x2=27.97,P＜0.01 )between them. Feeder vessels of CNV were found in 6 eyes(6.5% )by ICGA, and all were juxtafoveal and extrafoveal. Of 48 eyes with clear boundary CNV, 29 eyes (60.4%)with subfoveal CNV, 12 eyes (25.0%)with juxtafoveal CNV and 7 eyes (14.6%)with extrafoveal CNV. Conclusions Compared with FFA, ICGA may show CNV more clearly and the feeder vessel of CNV,and is more important to the clinical diagnosis and treatment of AMD.