| 淫羊藿不同提取物对D-半乳糖致衰老小鼠行为学及脏器指数的影响 |
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| 引用本文： | 李建平,张跃文,王静,方惠,张丽丹,陈素红,吕圭源. 淫羊藿不同提取物对D-半乳糖致衰老小鼠行为学及脏器指数的影响[J]. 中药药理与临床, 2010, 0(2) |
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| 作者姓名： | 李建平 张跃文 王静 方惠 张丽丹 陈素红 吕圭源 |
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| 作者单位： | 浙江中医药大学;河南中医学院; |
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| 基金项目： | 国家重点基础研究发展973计划(2007CB512603) |
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| 摘 要： | 目的:观察淫羊藿乙酸乙酯提取物和正丁醇提取物对D-半乳糖致衰老小鼠行为学和脏器指数的影响,探讨其抗衰老作用和功能药性部位。方法:采用D-半乳糖致衰老小鼠模型,分别灌胃给予53mg/kg、169mg/kg的淫羊藿乙酸乙酯提取物和85mg/kg、272mg/kg的淫羊藿正丁醇提取物,测试小鼠抓力、自主活动、悬尾及水迷宫的学习记忆成绩,并观察对脏器指数、骨骼重量和强度的影响。结果:淫羊藿乙酸乙酯提取物、正丁醇提取物均可明显缩短水迷宫测试到达平台的时间和游泳总路程,对抓力、悬尾实验、骨骼重量和强度无明显影响;淫羊藿正丁醇提取物低剂量组可减少小鼠的自主活动并增加睾丸指数。结论:淫羊藿乙酸乙酯提取物和正丁醇提取物能改善D-半乳糖致衰老小鼠的空间学习记忆能力,淫羊藿正丁醇提取物可增加睾丸指数。
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| 关 键 词： | 淫羊藿 D-半乳糖 抗衰老 学习记忆 脏器指数 |
Effects of Epimedium with different extracts on behavior and organ index of D-galactose-induced aging mice |
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| Li Jianping,,Zhang Yuewen,Wang Jin,Fang Hui,Zhang Lidan,Chen Suhong,Lv Guiyuan. Effects of Epimedium with different extracts on behavior and organ index of D-galactose-induced aging mice[J]. Pharmacology and Clinics of Chinese Materia Medica, 2010, 0(2) |
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| Authors: | Li Jianping Zhang Yuewen Wang Jin Fang Hui Zhang Lidan Chen Suhong Lv Guiyuan |
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| Affiliation: | Li Jianping1,2,Zhang Yuewen1,Wang Jin2,Fang Hui1,Zhang Lidan1,Chen Suhong1,Lv Guiyuan1(1 Zhejiang Chinese Medicine University,Hangzhou 310053,2 Henan University of Traditional Chinese Medicine,Zhengzhou 450008) |
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| Abstract: | Objective:To investigate the anti-aging effects and functional herbal nature site of Epimedium with different extracts on D-galactose (D-gal)-induced aging mice. Methods:The low-dose(53 mg/kg)and high-dose (169 mg/kg)of Epimedium ethyl acetate,low-dose(85 mg/kg)and high-dose (272 mg/kg)n-butanol extract were respectively given to the aging model mice by intragastric gavage. Then the behavioral characteristics,ability of learning and memory,organ index and effect on the bone were measured. Results:Epimedium ... |
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| Keywords: | Epimedium extracts D-galactose anti-aging learning and memory organ index |
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