| 肝脂酶与糖尿病及动脉粥样硬化的关系 |
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| 引用本文： | 王苑铭,田林红,陈慧,张娟.肝脂酶与糖尿病及动脉粥样硬化的关系[J].医学综述,2008,14(9):1365-1367. |
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| 作者姓名： | 王苑铭 田林红 陈慧 张娟 |
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| 作者单位： | 兰州大学第二医院内分泌科,兰州,730030 |
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| 摘 要： | 肝脂酶(HL)是脂蛋白代谢的关键酶之一,主要在肝细胞中合成,能水解各种脂蛋白中的三酰甘油和磷脂。肝脂酶基因(LIPC)变异是影响HL合成、活性改变的主要原因。LIPC启动子区有4个常见的呈连锁遗传的单核苷酸基因多态性,即-250G→A、-514C→T、-710T→C和-763A→G。LIPC的单核苷酸基因多态性与糖尿病、动脉粥样硬化等多种疾病具有相关性。
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| 关 键 词： | 肝脂酶 糖尿病 脂蛋白代谢 动脉粥样硬化 肝脂酶基因多态性 |
| 文章编号： | 1006-2084(2008)09-1365-03 |
| 修稿时间： | 2007年12月5日 |
The Relationship of Hepatic Lipase with Diabetes or Atherosclerosis |
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| WANG Yuan-ming,TIAN Lin-hong,CHEN Hui,ZHANG Juan.The Relationship of Hepatic Lipase with Diabetes or Atherosclerosis[J].Medical Recapitulate,2008,14(9):1365-1367. |
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| Authors: | WANG Yuan-ming TIAN Lin-hong CHEN Hui ZHANG Juan |
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| Institution: | WANG Yuan-ming,TIAN Lin-hong,CHEN Hui,ZHANG Juan.(Department of Endocrinology,The Second Hospital of Lanzhou University,Lanzhou 730030,China) |
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| Abstract: | Hepatic lipase is one of key enzyme during lipoprotein metabolism,which is mainly synthesized in live cells and can hydrolyze triacylglycerol and phospholipid of all kinds of lipoprotein.The mutation of hepatic lipase gene is the main reason affecting the synthesis and activity changes of HL.The four common found single-chain genetic gene nucleotide polymorphism(SNP)in the promoter region of LIPC are-250G→A,-514C→T,-710T→C and-763A→G.The SNP of hepatic lipase gene is associated with diabetes,atherosclerosis and other diseases. |
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| Keywords: | Hepatic lipase Diabetes Lipoprotein metabolism Atherosclerosis Hepatic lipase gene polymorphism |
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