月经第3天瘦素水平与体外受精-胚胎移植结局的关系

目的 :了解基础瘦素 (leptin)水平是否对体外受精 胚胎移植 (IVF ET)结局具有预测价值。方法 :选择90名不孕妇女共 90个IVF周期 ,比较妊娠组与非妊娠组血清激素水平及临床资料的差异。按leptin/体重指数(BMI)值分为 3组 ,比较各组IVF ET周期临床指标的差异。结果 :妊娠组具有较低的基础leptin、leptin/BMI水平。低leptin/BMI组具有较多的周期获卵数 ,较高的受精率、胚胎种植率、临床妊娠率。当leptin/BMI >0 .65时妊娠率明显降低。结论 :基础leptin/BMI对IVF ET结局具有较好的预测性。高血leptin会影响卵子与胚胎质量 ,从而使着床率降低 ,妊娠率也随之降低。

Initial explore the relationship between day 3 serum leptin levels and pregnancy outcome in vitro fertilization and embryo transfer cycles

Objective To explore the predictive va lue of the basal serum leptin levels to in vitro fertilization and embryo transf er (IVF-ET) outcome in infertile women. Methods Ninty infertile women who receive the IVF-ET treatme n t were chosen. To compared the serum hormone levels and clinical indices between the pregnancy team and inpregnancy team. The response to ovarian stimulation an d the pregnancy rates in different leptin/BMI (body mass index) levels teams wer e compared. Results The basal leptin and leptin/BMI levels were lower in pregnancy team. There were more mature oocytes retreived and the fertilization r ate, implantation rate, pregnancy rate were higher in low leptin/BMI levels team . The leptin/BMI>0.65 predicted significantly decreased pregnancy rates (P <0.05). Conclusion Basal FSH is a good index for predict the IVF-ET o utcome, elevated leptin levels particularly relative to BMI may impact the oocyt e and embryo quality, therefore the implantation rate decreased and the pregnanc y rate decreased either.