| 冬凌草甲素对麻醉开胸家兔血流动力学的作用 |
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| 引用本文： | 李琦 孙汉董. 冬凌草甲素对麻醉开胸家兔血流动力学的作用[J]. 中国药理学通报, 1992, 8(1): 53-55 |
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| 作者姓名： | 李琦 孙汉董 |
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| 作者单位： | 白求恩医科大学药理教研室 长春130021(李琦，陈正，刘洁)，中科院昆明植物研究所 650204(孙汉董)，中科院昆明植物研究所 650204(林中文) |
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| 摘 要： | 冬凌草甲素3.0mg,10.0mg/kg iv能使麻醉家兔心脏的LVSP,±dP/dt_(max),V_(pm),P-dP/dt,环体面积等均缩小,t-dP/dt_(max)延长,HR减慢,即负性肌力、负性频率作用。此外冬凌草甲素还具有明显的降压作用,其特点是DBP下降幅度大于SBP,推测冬凌草甲素可能具有抗扩张血管作用。
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| 关 键 词： | 冬凌草甲素 家兔 血流动力学 |
EFFECTS OF ORIDONIN ON THE HEMODYNAMICS IN ANAESTHETIZED RABBITS |
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| Li Qi,Chen Zheng,Liu Jie et al. EFFECTS OF ORIDONIN ON THE HEMODYNAMICS IN ANAESTHETIZED RABBITS[J]. Chinese Pharmacological Bulletin, 1992, 8(1): 53-55 |
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| Authors: | Li Qi Chen Zheng Liu Jie et al |
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| Abstract: | Oridonin is ent-kaurane diterpenoid and is one of the efficacious component of Rabdosia Rubesecens ( Hemel. ) Hara in Henan province. In this experiment, the effects of Oridonin on hemody-namics of anaesthetized rabbits were studied. Hemodynamics effects of Oridonin (3.0 mg, 10.0mg/kg iv)were noticed. LVSP, ±dP/dt_max, Vpm, Lo, HR, SBP, DBF were decreased. t-dP/dt_max was increased. LVEDP did not changed. Oridonin decreased DBP more than SBP, it is suggested that Oridonin. may reduce vascular smooth muscle tone. |
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| Keywords: | Oridonia Rabbit Hemodynamics |
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