Heparin as antibacterial agent in rabbit bladder. |
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Authors: | P M Hanno R Fritz A J Wein S G Mulholland |
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Affiliation: | From the Division of Urology, Department of Surgery, University of Pennsylvania School of Medicine, and the XT eterans Administration Hospital, Philadelphia, Pennsylvania, USA |
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Abstract: | Previous studies performed in our laboratory indicated that the primary antibacterial defense mechanism of the rabbit bladder is the antiadsorptive action of the surface mucopolysaccharide. The increased bacterial adsorption that occurs when the bladder is denuded of this layer was prevented by the instillation of heparin. Additional studies showed that the protective effect of heparin is inhibited by protamine, a further indication that the bladder's "antiadherence factor" is a mucopolysaccharide. Small amounts of heparin, applied directly to the mucoprotein-deficient bladder or to the surface of the inoculated bacteria, produced a statistically significant reduction in bacterial adsorption. |
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