螺内酯对老年高血压心力衰竭患者某些神经体液因子的影响

目的　探讨螺内酯对老年高血压心力衰竭患者血浆儿茶酚胺、肾素活性、血管紧张素Ⅱ及醛固酮的影响。方法　入选 32例老年高血压心力衰竭患者 ,随机分为螺内酯组与对照组 ,各 16例 ,用螺内酯治疗前与治疗 1个月 ,用高效液相色谱方法测定血浆去甲肾上腺素、肾上腺素 ,同时采用均相竞争放射免疫方法检测血浆肾素活性、血管紧张素Ⅱ与醛固酮。结果　螺内酯治疗 1个月的螺内酯组血浆去甲肾上腺素、肾上腺素明显低于治疗前 ,也低于对照组。结论　螺内酯可明显降低老年高血压心力衰竭患者的儿茶酚胺水平

Effect of spironolactone on some neurohormonal factors in elderly patients suffering cardiac insufficiency secondary to hypertension

Objective To determine the effects of spironolactone on neurohormonal factors,catecholamine,plasma renin activity,angiotensin Ⅱ and aldosterone in elderly patients suffering cardiac insufficiency secondary to hypertension.Methods Thirty two cases suffering cardiac insufficiency secondary to hypertension were selected and randomly enrolled into two groups,spironolactone group and control group,16 cases in each group.High pressure liquid chromatograph (HPLC)was used to detect plasma norepinephrine and adrenaline,plasma renin activity,angiotensin Ⅱ and aldosterone were also analysed by RIAs.Result Plasma norepinephrine and adrenaline in spironolactone group after 1 month treatment were significantly lower than that of the same group before spironolactone treatment and that of control one after 1 month routine therapy.Conclusions Spironolactone can significantly decrease plasma norepinephrine,adrenaline,these changes may be important mechanisms of spironolactone which could improve the prognosis of congestive heart failure.