慢性阻塞性肺疾病继发真菌感染临床研究

目的研究慢性阻塞性肺疾病（COPD）继发真菌感染患者的病原菌分布及耐药特点,指导临床用药。方法选取本院住院的COPD合并真菌感染的患者58例,对其痰液进行真菌培养鉴定,并进行药物敏感性试验。结果58例COPD继发真菌感染患者检测出白色念珠菌36例（62.07%）,热带念珠菌9例（15.52%）,克柔念珠菌8例（13.79%）,光滑念珠菌3例（5.17%）,曲霉菌2例（3.45%）。药敏结果显示白色念珠菌对制霉菌素、两性霉素B、伊曲康唑和5-氟尿嘧啶敏感性较高,对益康唑和酮康唑敏感性较低。结论COPD患者继发肺部真菌感染多为白色念珠菌感染。临床治疗时应选择针对性强、抗菌谱窄的抗生素。

Chronic Obstmctive Pulmonary Disease Secondary Fungal InfectiOns Clinical Research

Objective To study of chronic obstructive pulmonary disease （COPD） secondary fungal infection of the patients and drug--resistant bacteria distribution characteristics and clinical medicine.Methods The merger of hospital patients with COPD fungal infection of the 58 cases, sputum culture identification, and were fungi on drug sensitivity test. Results There were 58 cases of COPD patients with secondary fungal infection to detect candida albicans 36 cases （62.07%）,9 cases（tropical monilia krusei 15. 52%）,8 cases （monilia albicans 13.79%）, smooth 5.17% （3 cases）, 2 cases（aspergillns bionic）.Antimicrobial susceptibility test results show candida albicans of mould element, amphotericin B, sexes itraconazole and 5-fluorouracil and high sensitivity to merchant, and ketone health low sensitivity.Conclusion Patients with COPD secondary pulmonary fungus infection more for candida albicans infection.Clinical treatment should choose the pertinence, antibacterial spectrum narrow antibiotics.