实验性脑出血生长抑素-生长激素轴应变机制的研究

目的 观察脑出血血肿周边及下丘脑生长抑素（SS）的活性变化及其对相应区域生长激素（GH）的调控，探讨SS-GH应变紊乱对局部神经元内环境的影响。方法 采用实验性大鼠脑出血模型。应用放射免疫分析测定下丘脑及血肿周边的SS-GH含量。结果 血肿周边及远离血肿的下丘脑中S的含量明显升高，且与血肿量同步达高峰，与此同时，相应部位的GH含量亦呈明显上升趋势，结论 脑出血时血肿周边及下丘脑中SS含量升高的同时，相应部位GH的含量呈异常的上调趋势，反映了SS-GH轴在脑出血血肿形成的高峰期存在明显的应变紊乱。

Study on the mechanism of SS-GH axis responses in experimental intracerebral heMorrhage

Objective To observe the changes of SS activity and regulation of GH surrounding cerebral hemorrhage and the hypothalamus,and explore the disorder of SS GH to the affect of local neuronal internal circumstances in stress.Methods With intracerebral hemorrhage model in rats, SS GH content in the hypothalamus and cerebral hemorrhage periphery was determined using the radioimmunoassay.Results The SS content in the hypothalamus far from hematoma and the area surrounding cerebral hematoma elevated obviously, and reached its peak along with the hematoma content,meanwhile the GH content of relevant area trended to upregulate remarkably too.Conclusion While the SS content in the hypothalamus and the area surrounding cerebral hematoma elevated, the GH content of relevant area trended to rise remarkably too, the phenomenon indicated the stress disorder of SS GH axis during the highest peak of hematoma.