应用三维重建超声组织多普勒成像技术测量心肌梗死左室不同部位的射血分数:活体羊实验研究

目的用三维重建超声组织多普勒成像(3D TDI)方法,研究左室壁运动特点及左室不同部分的射血分数(EF).方法用重建的3D TDI的方法,对8只心尖部心肌梗死的活体羊模型在四种不同的血流状态下进行左室壁运动的测定和左室不同部分的EF测量.结果在四种不同的血流状态下,左室梗死区域的室壁运动振幅明显低于正常部分(P＜0.001),整个左室、左室正常部分的EF明显高于梗死部分(P＜0.001),左室正常部分的EF明显高于整个左室(0.0001＜P＜0.039).结论重建的3D TDI提供了一系列动态空间组织多普勒数据确定室壁异常运动区,并能测量左室不同部分的EF,在缺血性心脏疾病中,它有助于非侵入性心脏功能的估测.

Comparison of left ventricle ejection fraction by separately quantifying normal and infarctmyocardial cavity volume using three-dimensional tissue Doppler imaging:in-vivo sheep study

Objective: A new reconstructive three-dimensional tissue Doppler imaging (3D-TDI) method is used to characterize and quantify the left ventricular (LV) regional wall motion and test the ejection fraction (EF) of different part of LV. Methods: 8 sheep underwent occlusion of left anterior descending (LAD) coronary artery to create apical myocardial infarction and aneurysm formation, at which time 3D-TDI echo images were obtained by open-chest anesthetized animals. Under follow-up study, reconstructive 3D-TDI data were used to measure the LV regional wall motion and ejection fraction (EF) of whole LV and normal part of LV and ventricular aneurysm part in 4 different hemodynamic conditions for each sheep. Results: Wall motion amplitudes of normal part were significantly different from those of infracted apical area by t-test (P< 0.0001). The EF of the normal part of the LV and total LV were higher than that of the aneurysm segments (P<0.0001) and the EF for the normal part of the LV was higher than that of total LV (0.0001