| 地黄多糖b的免疫抑瘤作用及其机理 |
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| 引用本文： | 陈力真,冯杏婉.地黄多糖b的免疫抑瘤作用及其机理[J].中国药理学与毒理学杂志,1993,7(2):153-156. |
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| 作者姓名： | 陈力真 冯杏婉 |
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| 作者单位： | 军事医学科学院毒物药物研究所，军事医学科学院毒物药物研究所，军事医学科学院毒物药物研究所，军事医学科学院毒物药物研究所 北京 100850，北京 100850，北京 100850，北京 100850 |
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| 摘 要： | 从地黄中提取分离的多糖成分地黄多糖b(RPS-b),ip或ig给药抑制实体瘤S180的生长,ip给药对Lewis肺癌,B16黑素瘤和H22肝癌亦有效,最适有效剂量都在20mg·kg~(-1)体外实验证明,RPS-b对S180和HL60细胞生长均无明显的直接细胞毒作用.RPS-b在发挥抑瘤作用过程中,能提高S180荷瘤小鼠脾脏T淋巴细胞的增殖能力,并较长时间维持在较高水平;也能部分阻碍瘤株对脾脏天然杀伤细胞(NK)活力的抑制作用.说明RPS-b是一种免疫抑瘤的活性成份,其抑瘤作用是依赖于机体防御系统而间接产生的,增强机体的细胞免疫功能是其作用的重要机理
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| 关 键 词： | 地黄多糖 S180肉瘤 Lewis肺癌 B16黑素瘤 H22肝癌 HL60细胞系 T淋巴细胞 天然杀伤细胞 |
Immuno-tumoricidal effect of Rehmannia glutinosa polysaccharide b and its mechanism |
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| CHEN Li-Zhen,FENG Xing-Wan,ZHOU Jin-Huang,TANG Jian-Fang.Immuno-tumoricidal effect of Rehmannia glutinosa polysaccharide b and its mechanism[J].Chinese Journal of Pharmacology and Toxicology,1993,7(2):153-156. |
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| Authors: | CHEN Li-Zhen FENG Xing-Wan ZHOU Jin-Huang TANG Jian-Fang |
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| Abstract: | The polysaccharide fraction.Rehmannia glutinosa polysaccharide b(RPS b)was found to inhibit the growth of solid tumors S180,Lewis.B16,and H22 in mice by ip 20 40mg·kg-1 daily for 8 d since the second day of tumor transplantation.It was also effective by oral admin istration in experiments with S180 In vitro experiments.RPS b was ineffective in inhibiting the growth of S180 and HL60 cells.It showed a positive immunomodulatory activity by a prolonged elevation of the proliferation of the splenic T lymphocytes.Itcould also partly block the inhibition of NK.activity caused by tumor cell growth.These results demonstrate that RPS b is an effective antitumor agent through its immune modulatory particularly the cellular immune mechanism. |
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| Keywords: | Rehmannia glutinosapolysaccharide S180 sarcoma Lewis lungneoplasms B16 melanoma H22 liver neoplasms HL60 cell lines Tlymphocyte Natural killer cells |
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