High-Intensity Focused Ultrasound Leads to Histopathologic Changes of the Inferior Turbinate Mucosa with Allergic Inflammation |
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| Authors: | Hongquan Wei Lei Shi Jingru Zhang Yan Xia Jingjing Cuan Yong Zhang Wei Li Aihui Yan Xuejun Jiang Ming-Fei Lang Jing Sun |
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| Affiliation: | ∗ Department of Otolaryngology, First Hospital of China Medical University, Shenyang, Liaoning, China;† Department of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, China;‡ Department of Physiology, Dalian University Medical School, Dalian, Liaoning, China |
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| Abstract: | This study was aimed at understanding the histopathologic changes that occur in the nasal mucosa of patients with perennial allergic rhinitis after high-intensity focused ultrasound (HIFU) treatment. Biopsy specimens of the inferior turbinate mucosa were taken from 11 PAR patients before, immediately after and 1 y after HIFU treatment. Morphometric analysis revealed that the density of eosinophils and other inflammatory cells increased immediately after treatment and then were decreased significantly 1 y post-treatment. Submucosal glands were swollen and venous sinusoids were dilated, but there was no statistically significant change in their density, immediately after treatment. However, both glands and venous sinusoids significantly decreased in number 1 y after HIFU treatment. The ciliated epithelium or basement membrane of the nasal mucosa was well preserved at all stages. In conclusion, HIFU is a tolerable and effective treatment to reduce inflammation of the inferior turbinate mucosa in patients with perennial allergic rhinitis. |
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| Keywords: | High-intensity focused ultrasound Perennial allergic rhinitis Allergic inflammation Nasal mucosa |
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