Knockdown of TrkA in cumulus oocyte complexes (COCs) inhibits EGF-induced cumulus expansion by down-regulation of IL-6 |
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| Authors: | Yong Wang Ning Liang Guidong Yao Hui Tian Yiwen Zhai Yimeng Yin Fei Sun |
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| Affiliation: | 1. Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China;2. The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China |
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| Abstract: | |
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| Keywords: | NGF, nerve growth factor TrkA, tyrosine receptor kinase A COCs, cumulus oocyte complexes GCs, granulosa cells CCs, cumulus cells EGF, epidermal growth factor CEEFs, oocyte-secreted cumulus expansion-enabling factors Ptgs2, prostaglandin-endoperoxide synthase 2 Has2, hyaluronan synthase 2 Tnfaip6, TNF-induced protein 6 Ptx3, pentraxin 3 IL-6, interleukin-6 BMSC, bone marrow stromal cells eCG, equine chorionic gonadotropin ELISA, enzyme-linked immunosorbent assay |
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