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| 通腑汤对胃肠动力障碍大鼠小肠肌间神经丛中5-HT、SP和VIP含量的影响 | |
| 引用本文： | 寻庆英,杨德治,窦国祥,王翠芬,魏义全.通腑汤对胃肠动力障碍大鼠小肠肌间神经丛中5-HT、SP和VIP含量的影响[J].东南大学学报(医学版),2002,21(3):221-223. |
| 作者姓名： | 寻庆英 杨德治 窦国祥 王翠芬 魏义全 |
| 作者单位： | 1. 东南大学基础医学院,生理学教研室,江苏,南京,210009 2. 东南大学附属中大医院,中医内科,江苏,南京,210009 3. 东南大学基础医学院,药理学教研室,江苏,南京,210009 |
| 摘 要： | 目的：探讨通腑汤的药物作用及作用机制。方法：用甘草灌胃建立胃肠动力障碍动物模型；观察通腑汤对大鼠十二指肠，空肠肌间神经丛中5-羟色胺（5-HT），P-物质（SP）和血管活性肠肽（VIP）含量的影响。结果：与模型组比较，经通腑汤治疗6d后十二指肠肌间神经丛内5-HT，SP和VIP含量有显著性差异，5-HT，SP含量明显增加，VIP含量明显减少。结论：通腑汤可纠治甘草引起的胃肠动力障碍，使5-HT，SP，VIP的分泌恢复正常，说明通腑汤的药物作用机制与5-HT，SP和VIP的分泌密切相关。 |
| 关 键 词： | 通腑汤 胃肠动力 胃肠肽 免疫组织化学 动物模型 |
| 文章编号： | 1671-6264(2002)03-0221-03 |
| 修稿时间： | 2001年11月19 |
Effect of tongfu decoction on the content of 5-HT,SP,VIP in myenteric plexus of the small intestine in rats of gastrointestinal motility disorder |
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| XUN Qing ying ,YANG De zhi ,DOU Guo xiang ,WANG Cui fen ,WEI Yi quan.Effect of tongfu decoction on the content of 5-HT,SP,VIP in myenteric plexus of the small intestine in rats of gastrointestinal motility disorder[J].Journal of Southeast Univ: Medical Sci Ed,2002,21(3):221-223. | |
| Authors: | XUN Qing ying YANG De zhi DOU Guo xiang WANG Cui fen WEI Yi quan |
| Institution: | XUN Qing ying 1,YANG De zhi 1,DOU Guo xiang 2,WANG Cui fen 3,WEI Yi quan 1 |
| Abstract: | Objective To study the effects of Tongfu decoction on intestinal motility function in rats.Methods The animal model of gastrointestinal motility disorder in rats was established by licorice root decoction(LRD).And then,to observe the effects of Tongfu decoction on serotonin(5?HT),substance P (SP),vasoactive intestinal polypeptides(VIP) in myenteric nerve plexus of duodenum,jejunum of the models.Results There is a striking difference in the content of 5?HT,SP,and VIP in myenteric nerve plexus of duodenum after treatment of Tongfu decoction for 6 days.Tongfu decoction was able to increase the contents of 5?HT and SP,and decrease that of VIP in mytenteric nerve plexus of the models.Conclusion Tongfu decoction can recover normal motility function of intestinal of the animal model by increasing the contents of 5?HT and SP,and decreasing that of VIP in mytenteric nerve plexus of the models. |
| Keywords: | Tongfu decoction gastrointestinal motility gastrointestinal peptides immunohistochemistry rats |
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