早期关节活动对前交叉韧带重建后腱骨愈合的影响

背景：异体移植物可作为前交叉韧带重建翻修以及膝关节复合损伤修复的选择。目的：通过建立异体韧带移植重建前交叉韧带的动物模型，观察早期活动对异体植入物止点腱骨愈合的组织形态以及关节活动功能恢复的影响。方法：健康成年新西兰兔9只，随机取3只兔双侧跟腱作为供体，取6只兔切断一侧膝关节前交叉韧带，固定重建前交叉韧带。动物随机数字表法均分运动组和制动组，6周后观察关节活动功能、腱骨愈合大体观察以及组织学观察。结果与结论：术侧肢体活动情况基本正常，所有动物前交叉韧带上下止点愈合情况均良好。前交叉韧带周围滑膜均可见明显增生。活动组可见较多Sharpey纤维，腱骨间接连接形成，而制动组未见明裎Sharpey纤维。说明术后6周异体重建物止点已有腱骨愈合，早期活动对重建物的腱骨愈合并无明显不良影响，可能还更有利。

Early joint activities effect on the tendon-to-bone healing after anterior cruciate ligamen reconstruction in a rabbit model

BACKGROUND： AIIograft can be used as the selection for anterior cruciate ligament reconstruction and the repair of knee joint compound injury.. OBJECTIVE： To investigate the effects of early activities on the tissue morphology of tendon-to-bone healing of allograft and the recovery of joint function via the establishment of ligament allograft transplantation of anterior cruciate ligament reconstruction in a rabbit model. METHODS： Nine healthy adult New Zealand rabbits were selected. Three of them were collected and their bilateral achilles tendons served as donors. Then, six rabbits were collected and their one side of the anterior cruciate ligament of knee joints was cut off. Next, the anterior cruciate ligament was reconstructed. After that the anterior cruciate ligament was randomized into activity group and inactivity group. Finally, joint function and tendon-to-bone healing were observed by gross and histological observation at week 6 after surgery. RESULTS AND CONCLUSION： The results of observation showed that surgical limb activities were normal, and all rabbits＇ anterior cruciate ligament end points were healed well; the synovium around the anterior cruciate ligament were found obviously hyperplasy. Besides, More Sharpey fibers were observed in the activity group. Moreover, tendon bone formed and connected indirectly. While obvious Sharpey fibers were not seen in the inactivity group. These findings suggest that at week 6 after surgery, tendon-to-bone healing was found after allograft reconstruction. Early activities not only have no significant adverse effects on tendon-to-bone healing after anterior cruciate ligament reconstruction, but also may be more favorable.