板蓝根提取物抗甲1型流感病毒鼠肺适应株作用的研究

目的研究板蓝根提取液的抗甲1型流感病毒鼠肺适应株作用。方法以病毒滴鼻感染小鼠,建立病毒感染小鼠模型,观察小鼠病死率、肺指数及肺病理改变;用鸡胚培养法观察板蓝根提取物灭活甲1型流感病毒鼠肺适应株的作用。结果药物组小鼠病死率及肺指数明显低于模型组,有显著性差异。肺病理显示病变较模型组轻且炎性细胞渗出少。鸡胚实验结果显示板蓝根提取液能明显灭活病毒。结论板蓝根提取液具有一定的抗甲1型流感病毒鼠肺适应株和增强机体免疫力的作用。

Study of Radix isatidis extraction on mouse with influenza virus FMl strain

Objective It is to investigate the influence of Radix Isatidis extraction on mouse with influenza virus FM1 strain.Methods The mouse model was induced by nose dropping method with influenza virus.The lung index and death rate was observed;chicken embryo method was adopted in extracorporeal experiment of Radix Isatidis extraction on mouse with influenza virus FM1 strain.Results The lung index and death rate of drug groups had significantly difference compare with the model group;the pathological change of lung was improved.The Radix Isatidis extractive showed significant inactivation of influenza virus FM1 strain on chick-embryo culture.Conclusion Radix Isatidis extractive has antiviral effects on influenza virus FM1 strain.