广州地区心血管病患者血脂流行病学研究

目的 研究95年与05年广州地区心血管病患者的血脂水平在性别、年龄及不同人群间的差异以及十年间血脂变化情况。方法 采取整群抽样与非随机抽样的方法，回顾性调查了广州地区9家三甲医院1995年和2005年心内科住院病人，将其作为研究样本（6691人），然后对其血脂水平及分布特点进行统计学分析，计算心血管患者血脂标准化均数。 结果（1）调查人群TG、HDL-C平均水平为05年高于95分别依次为（1.51mmol/L vs.1.48mmol/L、1.14mmol/L vs.1.07mmol/L），而LDL-C、TC平均水平05年低于95年（2.81mmol/L vs. 3.05mmol/L、4.84 mmol/L vs. 4.88mmol/L）；（2）95年调查人群的血脂水平除HDL-C外均在性别上差异均无统计意义，表现为HDL-C女性高于男性（1.10mmol/L vs.1.04mmol/L）。有统计学差异(P=0.028)，而05年调查人群的血脂TG、HDL-C、LDL-C水平在性别上均有统计学差异，表现为TG男性高于女性（1.54 mmol/L vs.1.49 mmol/L）,HDL-C女性高于男性（1.22 mmol/L vs.1.08 mmol/L）, LDL-C女性高于男性（2.91 mmol/L vs. 2.74mmol/L），而TC无性别差异。结论 广州心血管病患者血脂水平十年来发生了显著性变化，95年与05年调查人群血脂平均水平均有显著性差异，TG、HDL-C9平均水平为05年高于95年，而LDL-C 、TC平均水平05年低于95年；95年及05年HDL-C水平均表现为女性高于男性。

Epidemiological study on plasma lipid among patients with cardiovascular disease in the Guang Zhou

Abstract] Objective To study the plasma lipid levels among patients with cardiovascular disease in Guangzhou in 1995 and 2005, and the changes of that in this decade. Method Representative samples of 6691 patients with Cardiovascular were obtained in Diseases in the Guangzhou region between 1995 and 2005. We devided these patients into six groups, including patients with hypertension, patients with coronary artery disease (CAD) or CAD risk equivalent, patients with both CAD and CAD risk equivalent, patients with CAD or CAD risk equivalent, patients with hypertension and CAD and CAD risk equivalent, and patients with the other cardiovascular disease. All the lipid data was analyzed by the department of Statistics. Results (1) There is obvious difference in average TG 、TC and HDL-、LDL-C levels in 1995 and 2005, and the TG、HDL-C levels in 2005 are higher than 1995.,but the LDL-C 、TC levels in 2005 are lower than 1995.Average LDL-C level also indicates remarkable discrepancy, with the level in 2005 lower than 1995. (2) Average TG, TC and LDL-C levels of male and female patients in 1995 show no marked difference, but average HDL-C level of female patients is higher than male patients. Average TG, HDL-C and LDL-C levels of male and female patients in 2005 indicate obvious difference, with the TG levels of male patients higher than female patients,and the the HDL-C、LDL-C levels of female patients higher than male patients. Conclusions Plasma lipid level of patients with cardiovascular diseases in Guangzhou Region has undergone remarkable changes during the ten years from 1995 to 2005. Keywords] coronary artery disease, plasma lipid, cardiovascular disease, dyslipidemia