hASH1基因与肺神经内分泌肿瘤的关系

肺神经内分泌肿瘤(neuroendocrine tumor，NET)是由具有多向分化潜能的肿瘤细胞组成，这些肿瘤细胞具有分泌多种活性激素的功能。肺NET的发生、发展与hASH1(human achaete-scute homologue 1), MEN1(multiple endocrine neoplasia type 1), pRB和E2F1等基因相关，其中hASH1基因成为近年来研究的热点，该基因能促进肺NET的内分泌分化，降低肿瘤的分化程度，并且有临床资料显示hASH1基因的表达还与小细胞肺癌的低生存率有关，可以作为临床预后的一个标准。

Relation between hASH1 and pulmonary neuroendocrine tumors

Pulmonary neuroendocrine tumors are comprised of multi-directional differentiation tumor cells which can secrete many species of active hormones.The amount of pulmonary neuroendocrine tumors accounts to one third of all lung cancers.It contains typical carcinoid(TC), atypical carcinoid（AC）, small cell lung cancer(SCLC)and large cell neuroendocrine carcinoma(LCNEC).The occurrence and development of pulmonary neuroendocrine tumors are related to many genes, like hASH1, MEN1, pRB and E2F1. The hASH1 is hot spot of study.The hASH1 can promote endocrine differentiation and cut down differentiation degree of pulmonary neuroendocrine tumors.It is reported that the express of hASH1 is related to survival rate of small cell lung cancer, suggesting that hASH1 can be a standard of clinic prognosis.