膳食锌缺乏对成年APPswe/PSEN1dE9双转基因小鼠学习记忆能力的影响

目的研究膳食锌缺乏对成年APPswe/PSEN1dE9双转基因小鼠学习记忆能力的影响。方法应用跳台试验观察膳食锌缺乏喂养50 d后,缺锌喂养组（zinc deficiency group,ZD）小鼠与阳性对照组（positive controlgroup,PG）和阴性对照组（negative control group,NC）小鼠学习记忆能力的差异。结果缺锌喂养50 d后,ZD组潜伏期由（126.30±106.43）s明显延长至（226.30±101.35）s,差异有显著性（P＆lt;0.05）。ZD组与NC组潜伏期分别为（226.30±101.35）s和（253.80±81.05）s,均明显较PC组（61.00±53.96）s长,差异有显著性意义（P＆lt;0.01）。ZD组与NC组5min错误次数分别为（1.4±1.9）次、（0.5±0.7）次,均低于PC组（3.8±2.9）次,差异有显著性（P＆lt;0.05）。结论缺锌喂养可能在一定程度上可以延缓成年APPswe/PSEN1dE9转基因小鼠学习记忆能力的下降。

The effect of dietary zinc deficiency on learning and memory capacity of APPswe/PSEN1dE9 double-transgenic mouse

Objective To investigate the effect of dietary zinc deficiency on learning and memory capacity in adult APPswe/PSENldE9 double-transgenic mice. Methods Platform-test was applied before and after 50 days experimental feeding to observe the differences of the learning and memory capacity among the mice of the dietary zinc deficiency group （ ZD）, the positive control group （ PC）, and the negative control group （NC）. The latency time and the number of errors committed by mice were recorded and analyzed. Results After 50 days of experimental feeding, the latency time of mice in ZD group markedly elongated, from （ 126.30 ± 106.43 ） s to （226.30 ± 101.35 ） s, and the difference was statistically significant （ P 〈 0.05 ）. The latency in both ZD and NC group was longer than that in PC group （ P 〈 0.01 ）. The mice in both ZD and NC groups displayed lesser errors in 5 min than those in PC group （ P 〈 0.05 ）. Conclusion The dietary zinc deficiency may delay learning and cause memory loss in the adult APPswe/PSEN1 dE9 double-transgenic mice.