Successful salvage therapy with daptomycin after linezolid and vancomycin failure in a liver transplant recipient with methicillin-resistant Staphylococcus aureus endocarditis |
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Authors: | S. Vernadakis F.H. Saner P.-M. Rath G.M. Kaiser Z. Mathe J. Treckmann A. Paul |
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Affiliation: | Department of General, Visceral, and Transplant Surgery, University Hospital Essen, Essen, Germany,;Institute of Medical Microbiology, University Essen, Essen, Germany |
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Abstract: | Abstract: Infective endocarditis is a rare complication affecting solid organ transplant recipients. Staphylococcus aureus is a common cause of infective endocarditis accounting for about 30% of cases. We present a case of nosocomial methicillin-resistant S. aureus endocarditis with persistent bacteremia, in a patient following orthotopic liver transplantation. We were unable to eradicate this infection with primary linezolid therapy or with secondary treatment with combined vancomycin and rifampicin, but successfully treated it with daptomycin, in addition to tricuspid and aortic valve replacement. |
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Keywords: | endocarditis liver transplantation methicillin-resistant Staphylococcus aureus (MRSA) daptomycin linezolid |
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