慢传输性便秘的病理生理研究进展

慢传输性便秘（STC）是常见的慢性顽固性便秘类型,临床症状顽固。综合的保守治疗往往效果不佳．临床滥用泻剂的现象较为普遍．但最终导致便秘的进行性加重,手术切除动力缓慢的结肠是目前最终的治疗选择。STC的病理生理机制至今不完全清楚．给临床防治带来极大的困难。STC结肠动力异常可能源于神经体液调控障碍．部分病人可表现为全消化道动力障碍。研究发现STC结肠VIP、SP、NOS等多种肠神经递质分布或含量异常．Cajal间质细胞数量减少。但长期服用刺激性泻剂也可导致结肠壁内神经类似的变化．因此上述异常改变究竟存在怎样的内在联系仍然是今后研究的重点。

Pathophysiology of slow transit constipation

Slow transit constipation(STC)is the common type of chronic idiopathic constipation. Due to failure of routine conservative treatment, laxatives abuse is the most choice for majority of the patients, which could damage the enteric nervous system and result in aggravation of constipation. Resection of the slow transit colon is the ultimate option for some patients. It is hard to prevent and treat STC clinically because of the unknown pathophysiologic mechanism. Abnormalities of enteric neurotransmitters such as VIP, SP, NOS and decreased number of interstitial cells of Cajal have been described in the colon of the patients with STC. However, long term application of stimulant laxatives can also result in the almost same changes in the colon. Exploration of the potential relationship among the above reported abnormalities is the direction of future study.